Peer-Reviewed Papers

Selection of Covers of our Best Papers:

Chronology of Publications (>290):

-V. Trimarco, R. Izzo, SS. Jankauskas, M. Fordellone, G. Signoriello, MV. Manzi, M. Lembo, P. Gallo, G. Esposito, R. Piccinocchi, F. Rozza, C. Morisco, P. Mone, G. Piccinocchi, F. Varzideh, B Trimarco, and G. Santulli. A six-year study in a real-world population reveals an increased incidence of dyslipidemia during COVID-19. Journal of Clinical Investigation 2024; In press.

-P. Mone, M. Ciccarelli, S. S. Jankauskas, G. Guerra, C. Vecchione, V. Visco, and G. Santulli. SGLT2 inhibitors and GLP-1 receptor agonists: which is the best anti-frailty drug? Lancet Healthy Longevity 2024. in press.

-F. Varzideh, B. Wang, Y. Qin, U. Kansakar, G. Santulli* (*Corresponding Author), SS. Jankauskas. Mechanistic role of mesencephalic astrocyte-derived neurotrophic factor in myocardial ischemia/reperfusion injury. Molecular Medicine 2024; in press.

-G. Santulli* (*Corresponding Author), F. Varzideh, Y. Qin, B. Wang, U. Kansakar, and SS. Jankauskas. Circulating levels of Cadherins are associated with atherosclerosis and cardiovascular outcomes. Journal of Molecular and Cellular Cardiology Plus; 2024. In press.

-F. Varzideh, S. S. Jankauskas, U. Jain, L. Soderquist, E. Densu Agyapong, U. Kansakar and G. Santulli. The dual endothelin-1 antagonist Aprocitentan alleviates mitochondrial oxidative stress in human cardiac fibroblasts. Eur Heart J Cardiovasc Pharmacother. 2024. https://doi.org/10.1093/ehjcvp/pvae050; PMID:38977898.

-G. Santulli, V. Visco, F. Varzideh, G. Guerra, U. Kansakar, M. Gasperi, A. Marro, S. Wilson, M. N. V. Ferrante, A. Pansini, A. Pirone, F. Di Lorenzo, D. Tartaglia, G. Iaccarino, G. Macina, E. D. Agyapong, I. Forzano, S. S. Jankauskas, K. Komici, M. Ciccarelli and P. Mone. Prediabetes increases the risk of frailty in prefrail older adults with hypertension: Beneficial effects of metformin. Hypertension. 2024;81:1637-1643. https://doi.org/10.1161/hypertensionaha.124.23087; PMID:38752357. [Journal Cover]

-V. Trimarco, R. Izzo, D. Pacella, U. Trama, M. V. Manzi, A. Lombardi, R. Piccinocchi, P. Gallo, G. Esposito, G. Piccinocchi, M. Lembo, C. Morisco, F. Rozza, G. Santulli* (*Co-Last Author, Corresponding Author), B. Trimarco. Incidence of new-onset hypertension before, during, and after the COVID-19 pandemic: A 7-year longitudinal cohort study in a large population. BMC Medicine. 2024;22:127. https://doi.org/10.1186/s12916-024-03328-9; PMID:38500180.

-V. Trimarco, R. Izzo, P. Gallo, M. V. Manzi, I. Forzano, D. Pacella, G. Santulli* (*Co-Last Author, Corresponding Author), B. Trimarco. Long-lasting control of LDL cholesterol induces a 40% reduction in the incidence of cardiovascular events: New insights from a 7-year study. J Pharmacol Exp Ther (JPET). 2024;388:742-747. https://doi.org/10.1124/jpet.123.001878; PMID:37775305. [With Editorial Commentary]

-B. Trimarco and G. Santulli. Dietary supplements in cardiovascular and metabolic diseases. Nutrients. 2024;16:1418. https://doi.org/10.3390/nu16101418; PMID:38794656.

-M. Savino, L. Savino, P. Mone, C. Schiano, A. De Luca and G. Santulli. Predicting exercise intolerance in elderly individuals with heart failure using the 30-second chair stand test. Int J Cardiol Heart Vasc. 2024;53:101464. https://doi.org/10.1016/j.ijcha.2024.101464; PMID:39228978.

-L. Savino, M. Savino, U. Kansakar, T. Dazzetti, F. Varzideh, S. S. Jankauskas, P. Mone and G. Santulli. Extracellular RNA and endothelial TLR3 link inflammation and venous thromboembolism. J Am Heart Assoc (JAHA). 2024;13:e036335. https://doi.org/10.1161/jaha.124.036335; PMID:39028039.

-G. Santulli, V. Visco, M. Ciccarelli, M. N. V. Ferrante, P. De Masi, A. Pansini, N. Virtuoso, A. Pirone, G. Guerra, V. Verri, G. Macina, A. Taurino, K. Komici and P. Mone. Frail hypertensive older adults with prediabetes and chronic kidney disease: Insights on organ damage and cognitive performance - preliminary results from the CARYATID study. Cardiovasc Diabetol. 2024;23:125. https://doi.org/10.1186/s12933-024-02218-x; PMID:38600564.

-G. Santulli, M. Savino, K. Komici, P. Mone, L. Savino and S. S. Jankauskas. A novel imaging marker for asymptomatic cerebrovascular lesions in hypertension. Am J Hypertens. 2024. https://doi.org/10.1093/ajh/hpae100; PMID:39094226.

-P. Mone, V. Trimarco, M. Morgante, B. Trimarco and G. Santulli. Combining L-Arginine and Vitamin C improves physical frailty in hypertensive elders. Eur J Intern Med. 2024. https://doi.org/10.1016/j.ejim.2024.08.011; PMID:39164155.

-P. Mone, V. Trimarco, U. Kansakar, R. Izzo, G. Santulli* (*Corresponding Author), B. Trimarco. Combining choline bitartrate and Vitamin B12 ameliorates cognitive impairment in hypertensive elders with cognitive frailty. Pharmacological Research. 2024;201:107103. https://doi.org/10.1016/j.phrs.2024.107103; PMID:38336310.

-P. Mone, S. S. Jankauskas, M. V. Manzi, J. Gambardella, A. Coppola, U. Kansakar, R. Izzo, G. Fiorentino, A. Lombardi, F. Varzideh, D. Sorriento, B. Trimarco and G. Santulli. Endothelial extracellular vesicles enriched in microRNA-34a predict new-onset diabetes in coronavirus disease 2019 (COVID-19) patients: Novel insights for long COVID metabolic sequelae. J Pharmacol Exp Ther. 2024;389:34-39. https://doi.org/10.1124/jpet.122.001253; PMID:38336381.

-P. Mone, G. Guerra, S. Verderosa, G. Santulli and K. Komici. Effects of moderate caffeine intake in athletes. Eur J Intern Med. 2024;119:139-140. https://doi.org/10.1016/j.ejim.2023.09.018; PMID:37775431.

-P. Mone, G. Guerra, A. Lombardi, M. Illario, A. Pansini, A. Marro, S. Frullone, A. Taurino, D. Sorriento, V. Verri, G. Iaccarino and G. Santulli. Effects of SGLT2 inhibition via empagliflozin on cognitive and physical impairment in frail diabetic elders with chronic kidney disease. Pharmacol Res. 2024;200:107055. https://doi.org/10.1016/j.phrs.2023.107055; PMID:38176528.

-P. Mone, A. De Luca, U. Kansakar and G. Santulli. Leukocytes and endothelial cells participate in the pathogenesis of Alzheimer's disease: Identifying new biomarkers mirroring metabolic alterations. J Alzheim Dis. 2024;97:1685-1687. https://doi.org/10.3233/jad-231464; PMID:38306052.

-P. Mone, L. Bencivenga, G. Santulli, G. Rengo, G. Guerra and K. Komici. Time to negative conversion and cardiopulmonary performance in athletes with COVID-19. European Respiratory Journal Open Res. 2024;10. https://doi.org/10.1183/23120541.00090-2024; PMID:39040592.

-P. Mone, E. D. Agyapong, G. Morciano, S. S. Jankauskas, A. De Luca, F. Varzideh, P. Pinton and G. Santulli. Dysfunctional mitochondria elicit bioenergetic decline in the aged heart. J Cardiovasc Aging. 2024;4. https://doi.org/10.20517/jca.2023.50; PMID:39015481.

-M. Lembo, V. Trimarco, R. Izzo, M. V. Manzi, F. Rozza, P. Gallo, C. Morisco, L. Bardi, G. Esposito, I. Forzano, G. Santulli* (*Co-Last Author, Corresponding Author), B. Trimarco. Achieving a systolic blood pressure below 130 mmhg reduces the incidence of cardiovascular events in hypertensive patients with echocardiographic left ventricular hypertrophy. J Pharmacol Exp Ther. 2024;390:4-10. https://doi.org/10.1124/jpet.123.001952; PMID:38135511. [With Editorial Commentary by Dr. Franz H. Messerli]

-U. Kansakar, V. Trimarco, M. V. Manzi, E. Cervi, P. Mone and G. Santulli. Exploring the therapeutic potential of bromelain: Applications, benefits, and mechanisms. Nutrients. 2024;16. https://doi.org/10.3390/nu16132060; PMID:38999808.

-S. S. Jankauskas, F. Varzideh, P. Mone, U. Kansakar, F. Di Lorenzo, A. Lombardi and G. Santulli. Interleukin-1 receptor associated kinase 2 is a functional downstream regulator of Complement Factor D that controls mitochondrial fitness in diabetic cardiomyopathy. Mil Med Res. 2024;11:1. https://doi.org/10.1186/s40779-023-00506-3; PMID:38167325.

-S. S. Jankauskas, F. Varzideh, U. Kansakar, G. Al Tibi, E. Densu Agyapong, J. Gambardella and G. Santulli. Insights into molecular and cellular functions of the golgi calcium/manganese-proton antiporter tmem165. J Biol Chem (JBC). 2024;300:107567. https://doi.org/10.1016/j.jbc.2024.107567; PMID:39002685.

-J. Gambardella, F. Varzideh, S. S. Jankauskas, U. Kansakar, S. Sidoli, A. Lombardi and G. Santulli. Ketogenic diet improves chromatin remodeling and rescues mitochondrial dysfunction in ischemic heart disease by regulating pgc-1alpha transcription. Vascul Pharmacol. 2024;155:107348. https://doi.org/10.1016/j.vph.2024.107348; PMID:38985626.

-J. Gambardella, S. S. Jankauskas, U. Kansakar, F. Varzideh, R. Avvisato and G. Santulli. COVID-19 causes the opening of the mitochondrial permeability transition pore in human endothelial cells. Vascular Pharmacology. 2024;155:107349. https://doi.org/10.1016/j.vph.2024.107349; PMID:38985627.

-I. Forzano and G. Santulli. Patent foramen ovale: The unresolved questions. Top Ital Sci Journal. 2024;1. https://doi.org/10.62684/dmfz6956; PMID:38585657.

-J. Gambardella, A. Fiordelisi, F. A. Cerasuolo, A. Buonaiuto, R. Avvisato, A. Viti, E. Sommella, P. Campiglia, V. D'Argenio, N. Prevete, S. D'Apice, F. Varzideh, R. Paolillo, C. Perrino, E. Riccio, A. Pisani, A. Bianco, J. Sadoshima, L. Spinelli, G. Santulli, D. Sorriento and G. Iaccarino. Early impairment in mitochondrial quality check and function precedes the development of cardiac phenotypes in an mouse model of Fabry disease. Vascul Pharmacol. 2024;155:107320. https://doi.org/10.1016/j.vph.2024.107320; PMID:38985588.

-M. Ferrone, M. Ciccarelli, F. Varzideh, U. Kansakar, G. Guerra, F. A. Cerasuolo, A. Buonaiuto, A. Fiordelisi, E. Venga, M. Esposito, A. Rainone, R. Ricciardi, C. Del Giudice, F. Minicucci, T. Tesorio, V. Visco, G. Iaccarino, J. Gambardella, G. Santulli and P. Mone. Endothelial microRNAs in INOCA patients with diabetes mellitus. Cardiovasc Diabetol. 2024;23:268. https://doi.org/10.1186/s12933-024-02331-x; PMID:39039512.

-F. A. Cerasuolo, J. Gambardella, G. Santulli, A. Fiordelisi, X. Wang, N. Prevete, E. Sommella, R. Avvisato, A. Buonaiuto, G. G. Altobelli, M. Ciccarelli, C. Morisco, J. Sadoshima, G. Iaccarino and D. Sorriento. Macrophages participate in doxorubicin-induced cardiac damage. Vascul Pharmacol. 2024;155:107309. https://doi.org/10.1016/j.vph.2024.107309; PMID:38985612.

-A. Buonaiuto, J. Gambardella, G. Santulli, A. Fiordelisi, X. Wang, N. Prevete, E. Sommella, R. Avvisato, F. A. Cerasuolo, G. G. Altobelli, M. Ciccarelli, C. Morisco, J. Sadoshima, G. Iaccarino and D. Sorriento. Macrophages release miRNAs in response to doxorubicin with a potential role in indirect cardiac damage. Vascul Pharmacol. 2024;155:107302. https://doi.org/10.1016/j.vph.2024.107302; PMID:38985604.

-R. Avvisato, S. S. Jankauskas, P. Mone, U. Kansakar, F. Varzideh, S. De Gennaro, L. Salemme, A. Cioppa, S. Frullone, G. Macina, M. Di Mauro, T. Tesorio, J. Gambardella and G. Santulli. miR-181c modulates SMAD7 and Parkin in human cardiac fibroblasts: Validation in frail older adults with diabetes and HFpEF. Vascul Pharmacol. 2024;155:107350. https://doi.org/10.1016/j.vph.2024.107350; PMID:38985628.

-P. Mone, G. Guerra and G. Santulli. Complete or culprit-only PCI in older patients with MI. N Engl J Med. 2023;389:1923-1924. https://doi.org/10.1056/NEJMc2311551; PMID:37966296.

-G. Santulli. Cardiac sarcoidosis: Updated insights on epidemiology and diagnostic criteria. Am J Cardiol. 2023;204:425-427. https://doi.org/10.1016/j.amjcard.2023.07.123; PMID:37599180.

-J. Gambardella, S. S. Jankauskas, U. Kansakar, F. Varzideh, R. Avvisato, N. Prevete, S. Sidoli, P. Mone, X. Wang, A. Lombardi and G. Santulli. Ketone bodies rescue mitochondrial dysfunction via epigenetic remodeling. JACC Basic Transl Sci. 2023;8:1123-1137. https://doi.org/10.1016/j.jacbts.2023.03.014; PMID:37791311. [With Editorial Commentary by Dr. Junichi Sadoshima]

-G. Santulli, S. S. Jankauskas, F. Varzideh, P. Mone and U. Kansakar. Targeting cardiovascular and metabolic disorders through annual nationwide screening and lifestyle intervention: Insights from a cohort of 5 819 041 subjects with a 4-year follow-up. Eur J Prev Cardiol. 2023;30:329-330. https://doi.org/10.1093/eurjpc/zwac302; PMID:36529466.

-F. Varzideh, J. Gambardella, U. Kansakar, S. S. Jankauskas and G. Santulli. Molecular mechanisms underlying pluripotency and self-renewal of embryonic stem cells. Int J Mol Sci. 2023;24. https://doi.org/10.3390/ijms24098386; PMID:37176093.

-P. Mone, U. Kansakar, A. Lucariello, A. Marro, A. Pansini, F. Varzideh, G. Nittolo, L. De Angelis, V. Trimarco, G. Martinelli, A. De Luca and G. Santulli. Choline supplementation improves cognitive performance in frail hypertensive patients: Novel insights on endothelial function from the INTERVENTIONIST study. Eur J Prev Cardiol. 2023. https://doi.org/10.1093/eurjpc/zwad120; PMID:37070474.

-V. Trimarco, M. V. Manzi, R. Izzo, P. Mone, M. Lembo, D. Pacella, G. Esposito, A. Falco, C. Morisco, P. Gallo, G. Santulli* (*Corresponding Author), and B. Trimarco. The therapeutic concordance approach reduces adverse drug reactions in patients with resistant hypertension. Front Cardiovasc Med. 2023;10:1137706. https://doi.org/10.3389/fcvm.2023.1137706; PMID:37215551.

-T. Tesorio, P. Mone, A. de Donato, V. Trimarco and G. Santulli. Linking lifestyle factors to cardiovascular risk through metabolomics: Insights from a large population of diabetic patients followed-up for 11 years. Atherosclerosis. 2023;367:37-39. https://doi.org/10.1016/j.atherosclerosis.2023.01.012; PMID:36725416.

-G. Santulli* (*Corresponding Author),  C. M. Pabelick, Y. K. Jan, P. Denise and C. de Lucia. Methods and applications in clinical and translational physiology. Frontiers in Physiology. 2023;14:1169544. https://doi.org/10.3389/fphys.2023.1169544; PMID:37008021.

-V. Trimarco, R. Izzo, P. Mone, M. Lembo, M. V. Manzi, D. Pacella, A. Falco, P. Gallo, G. Esposito, C. Morisco, G. Santulli* (*Corresponding Author), and B. Trimarco. Therapeutic concordance improves blood pressure control in patients with resistant hypertension. Pharmacol Res. 2023;187:106557. https://doi.org/10.1016/j.phrs.2022.106557; PMID:36402254.

-C. Sardu, G. Santulli and D' Onofrio N. Influence of lifestyle factors in the management of diabetes mellitus. Front Endocrinol. 2023;14:1258766. https://doi.org/10.3389/fendo.2023.1258766; PMID:37635961.

-P. Mone, A. Lombardi, L. Salemme, A. Cioppa, G. Popusoi, F. Varzideh, A. Pansini, S. S. Jankauskas, I. Forzano, R. Avvisato, X. Wang, T. Tesorio and G. Santulli. Stress hyperglycemia drives the risk of hospitalization for chest pain in patients with ischemia and nonobstructive coronary arteries (INOCA). Diabetes Care. 2023;46:450-454. https://doi.org/10.2337/dc22-0783; PMID:36478189.

-L. Sasset, O. L. Manzo, Y. Zhang, A. Marino, L. Rubinelli, M. A. Riemma, M. L. S. Chalasani, D. C. Dasoveanu, F. Roviezzo, S. S. Jankauskas, G. Santulli, M. R. Bucci, T. T. Lu and A. Di Lorenzo. Nogo-A reduces ceramide de novo biosynthesis to protect from heart failure. Cardiovasc Res. 2023;119:506-519. https://doi.org/10.1093/cvr/cvac108; PMID:35815623.

-V. Trimarco, R. Izzo, A. Lombardi, A. Coppola, G. Fiorentino and G. Santulli. Beneficial effects of L-Arginine in patients hospitalized for COVID-19: New insights from a randomized clinical trial. Pharmacol Res. 2023;191:106702. https://doi.org/10.1016/j.phrs.2023.106702; PMID:36804278.

-C. Sardu, G. Santulli, G. Savarese, M. C. Trotta, C. Sacra, M. Santamaria, M. Volpicelli, A. Ruocco, C. Mauro, G. Signoriello, L. Marfella, M. D'Amico, R. Marfella and G. Paolisso. Endothelial dysfunction drives CRTd outcome at 1-year follow-up: A novel role as biomarker for miR-130a-5p. Int J Mol Sci. 2023;24. https://doi.org/10.3390/ijms24021510; PMID:36675028.

-G. Santulli, F. Varzideh, I. Forzano, S. Wilson, L. Salemme, A. de Donato, A. Lombardi, A. Rainone, L. Nunziata, S. S. Jankauskas, T. Tesorio, G. Guerra, U. Kansakar and P. Mone. Functional and clinical importance of SGLT2-inhibitors in frailty: From the kidney to the heart. Hypertension. 2023;80:1800-1809. https://doi.org/10.1161/hypertensionaha.123.20598; PMID:37403685. [Journal cover]

-P. Paolisso, L. Bergamaschi, F. Gragnano, E. Gallinoro, A. Cesaro, C. Sardu, N. Mileva, A. Foà, M. Armillotta, A. Sansonetti, S. Amicone, A. Impellizzeri, G. Esposito, N. Morici, O. J. Andrea, G. Casella, C. Mauro, D. Vassilev, N. Galie, G. Santulli, R. Marfella, P. Calabrò, E. Barbato and C. Pizzi. Reply to SGLT-2 inhibitors: Post-infarction interventional effects. Pharmacol Res. 2023;189:106664. https://doi.org/10.1016/j.phrs.2023.106664; PMID:36642618.

-G. Santulli. Non-coding RNAs in clinical practice: From biomarkers to therapeutic tools. J Pharmacol Exp Ther. 2023;384:225-226. https://doi.org/10.1124/jpet.122.001457; PMID:36581351. [Journal Cover]

-M. Luo and G. Santulli. The link between obesity, type 2 diabetes, and mitochondria. Front Endocrinol. 2023;14:1229935. https://doi.org/10.3389/fendo.2023.1229935; PMID:37409237.

-G. Santulli. Translational aspects of cardiovascular biology: From bench to bedside. Biology. 2023;12:658. https://doi.org/10.3390/biology12050658; PMID:37237472.

-P. Mone, G. Martinelli, A. Lucariello, A. L. Leo, A. Marro, S. De Gennaro, S. Marzocco, D. Moriello, S. Frullone, L. Cobellis and G. Santulli. Extended-release metformin improves cognitive impairment in frail older women with hypertension and diabetes: Preliminary results from the LEOPARDESS study. Cardiovasc Diabetol. 2023;22:94. https://doi.org/10.1186/s12933-023-01817-4; PMID:37085892.

-G. Santulli. Editorial: Insights in cardiovascular endocrinology: 2023. Front Endocrinol. 2023;14:1266221. https://doi.org/10.3389/fendo.2023.1266221; PMID:37600701.

-P. Paolisso, L. Bergamaschi, F. Gragnano, E. Gallinoro, A. Cesaro, C. Sardu, N. Mileva, A. Foà, M. Armillotta, A. Sansonetti, S. Amicone, A. Impellizzeri, G. Esposito, N. Morici, O. J. Andrea, G. Casella, C. Mauro, D. Vassilev, N. Galie, G. Santulli, R. Marfella, P. Calabrò, C. Pizzi and E. Barbato. Outcomes in diabetic patients treated with SGLT2-inhibitors with acute myocardial infarction undergoing pci: The SGLT2-i AMI protect registry. Pharmacol Res. 2023;187:106597. https://doi.org/10.1016/j.phrs.2022.106597; PMID:36470546.

-P. Paolisso, L. Bergamaschi, A. Cesaro, E. Gallinoro, F. Gragnano, C. Sardu, N. Mileva, A. Foà, M. Armillotta, A. Sansonetti, S. Amicone, A. Impellizzeri, M. Belmonte, G. Esposito, N. Morici, J. Andrea Oreglia, G. Casella, C. Mauro, D. Vassilev, N. Galie, G. Santulli, P. Calabrò, E. Barbato, R. Marfella and C. Pizzi. Impact of SGLT2-inhibitors on contrast-induced acute kidney injury in diabetic patients with acute myocardial infarction with and without chronic kidney disease: Insight from SGLT2-i AMI protect registry. Diabetes Res Clin Pract. 2023;202:110766. https://doi.org/10.1016/j.diabres.2023.110766; PMID:37276980.

-P. Mone, X. Wang, V. Trimarco and G. Santulli. Re: Differential benefits of physical training associated or not with l-arginine supplementation in rats with metabolic syndrome: Evaluation of cardiovascular, autonomic and metabolic parameters. Physiol Behav. 2023;269:114274. https://doi.org/10.1016/j.physbeh.2023.114274; PMID:37331457.

-G. Santulli, U. Kansakar, F. Varzideh, P. Mone, S. S. Jankauskas and A. Lombardi. Functional role of taurine in aging and cardiovascular health: An updated overview. Nutrients. 2023;15. https://doi.org/10.3390/nu15194236; PMID:37836520.

-J. Gambardella, A. Fiordelisi, D. Sorriento, F. Cerasuolo, A. Buonaiuto, R. Avvisato, A. Pisani, F. Varzideh, E. Riccio, G. Santulli* (*Co-Last Author, Co-Corresponding Author),  and G. Iaccarino. Mitochondrial microRNAs are dysregulated in patients with Fabry disease. J Pharmacol Exp Ther. 2023;384:72-78. https://doi.org/10.1124/jpet.122.001250; PMID:35764328. [Journal Cover]

-I. Forzano, R. Avvisato, F. Varzideh, S. S. Jankauskas, A. Cioppa, P. Mone, L. Salemme, U. Kansakar, T. Tesorio, V. Trimarco and G. Santulli. L-Arginine in diabetes: Clinical and preclinical evidence. Cardiovasc Diabetol. 2023;22:89. https://doi.org/10.1186/s12933-023-01827-2; PMID:37072850.

-P. Mone, A. De Luca and G. Santulli. Frailty and oxidative stress. Frontiers in Aging. 2023;4:1345486. https://doi.org/10.3389/fragi.2023.1345486; PMID:38510261.

-V. Parra, G. Monaco, G. Morciano and G. Santulli. Editorial: Mitochondrial remodeling and dynamic inter-organellar contacts in cardiovascular physiopathology - Volume II. Front Cell Dev Biol. 2023;11:1240207. https://doi.org/10.3389/fcell.2023.1240207; PMID:37427376.

-P. Mone, T. Tesorio, A. De Donato, A. Cioppa, S. S. Jankauskas, L. Salemme and G. Santulli. A novel urinary proteomic classifier predicts the risk of coronary artery disease. Eur J Prev Cardiol. 2023;30:1535-1536. https://doi.org/10.1093/eurjpc/zwad123; PMID:37075225.

-R. Marfella, F. Prattichizzo, C. Sardu, P. Paolisso, N. D'Onofrio, L. Scisciola, R. La Grotta, C. Frigé, F. Ferraraccio, I. Panarese, M. Fanelli, P. Modugno, A. M. Calafiore, M. Melchionna, F. C. Sasso, F. Furbatto, D. D'Andrea, M. Siniscalchi, C. Mauro, A. Cesaro, P. Calabrò, G. Santulli, M. L. Balestrieri, E. Barbato, A. Ceriello and G. Paolisso. Evidence of an anti-inflammatory effect of PCSK9 inhibitors within the human atherosclerotic plaque. Atherosclerosis. 2023;378:117180. https://doi.org/10.1016/j.atherosclerosis.2023.06.971; PMID:37422356.

-Y. H. Kao, Y. J. Chen, S. Higa, N. Chattipakorn and G. Santulli. Transcription factors and arrhythmogenesis. Front Physiol. 2023;14:1169747. https://doi.org/10.3389/fphys.2023.1169747; PMID:36926195.

-P. Mone, S. De Gennaro, D. Moriello, S. Frullone, R. D'Amelio, M. N. V. Ferrante, A. Marro and G. Santulli. Insulin resistance drives cognitive impairment in hypertensive pre-diabetic frail elders: The CENTENNIAL study. Eur J Prev Cardiol. 2023;30:1283-1288. https://doi.org/10.1093/eurjpc/zwad173; PMID:37196030.

-U. Kansakar, V. Trimarco, P. Mone, F. Varzideh, A. Lombardi and G. Santulli. Choline supplements: An update. Front Endocrinol. 2023;14:1148166. https://doi.org/10.3389/fendo.2023.1148166; PMID:36950691.

-P. Mone, A. Lombardi, U. Kansakar, F. Varzideh, S. S. Jankauskas, A. Pansini, S. Marzocco, S. De Gennaro, M. Famiglietti, G. Macina, S. Frullone and G. Santulli. Empagliflozin improves the microRNA signature of endothelial dysfunction in patients with heart failure with preserved ejection fraction and diabetes. J Pharmacol Exp Ther. 2023;384:116-122. https://doi.org/10.1124/jpet.121.001251; PMID:36549862. [Journal Cover]

-S. S. Jankauskas, P. Mone, R. Avvisato, F. Varzideh, S. De Gennaro, L. Salemme, G. Macina, U. Kansakar, A. Cioppa, S. Frullone, J. Gambardella, M. Di Mauro, T. Tesorio and G. Santulli. miR-181c targets Parkin and SMAD7 in human cardiac fibroblasts: Validation of differential microRNA expression in patients with diabetes and heart failure with preserved ejection fraction. Mech Ageing Dev. 2023;212:111818. https://doi.org/10.1016/j.mad.2023.111818; PMID:37116731.

-R. Izzo, D. Pacella, V. Trimarco, M. V. Manzi, A. Lombardi, R. Piccinocchi, P. Gallo, G. Esposito, M. Lembo, G. Piccinocchi, C. Morisco, G. Santulli and B. Trimarco. Incidence of type 2 diabetes before and during the COVID-19 pandemic in Naples, Italy: A longitudinal cohort study. Lancet - eClinicalMedicine. 2023;66:102345. https://doi.org/10.1016/j.eclinm.2023.102345; PMID:38143804.

-S. S. Jankauskas, U. Kansakar, C. Sardu, F. Varzideh, R. Avvisato, X. Wang, A. Matarese, R. Marfella, M. Ziosi, J. Gambardella and G. Santulli. COVID-19 causes ferroptosis and oxidative stress in human endothelial cells. Antioxidants. 2023;12. https://doi.org/10.3390/antiox12020326; PMID:36829885.

-J. Gambardella, G. Santulli, A. Fiordelisi, F. A. Cerasuolo, X. Wang, N. Prevete, E. Sommella, R. Avvisato, A. Buonaiuto, G. G. Altobelli, L. Rinaldi, F. Chiuso, A. Feliciello, F. Dal Piaz, P. Campiglia, M. Ciccarelli, C. Morisco, J. Sadoshima, G. Iaccarino and D. Sorriento. Infiltrating macrophages amplify doxorubicin-induced cardiac damage: Role of catecholamines. Cell Mol Life Sci. 2023;80:323. https://doi.org/10.1007/s00018-023-04922-5; PMID:37819449.

-J. Gambardella, U. Kansakar, C. Sardu, V. Messina, S. S. Jankauskas, R. Marfella, P. Maggi, X. Wang, P. Mone, G. Paolisso, D. Sorriento and G. Santulli. Exosomal miR-145 and miR-885 regulate thrombosis in COVID-19. J Pharmacol Exp Ther. 2023;384:109-115. https://doi.org/10.1124/jpet.122.001209; PMID:35772782. [Journal Cover]

-P. Mone, S. De Gennaro, S. Frullone, A. Marro and G. Santulli. Hyperglycemia drives the transition from pre-frailty to frailty: The MONTEFORTE study. Eur J Intern Med. 2023;111:135-137. https://doi.org/10.1016/j.ejim.2023.01.006; PMID:36635128.

-J. Gambardella, A. Fiordelisi, F. A. Cerasuolo, A. Buonaiuto, R. Avvisato, A. Viti, E. Sommella, F. Merciai, E. Salviati, P. Campiglia, V. D'Argenio, S. Parisi, A. Bianco, L. Spinelli, E. Di Vaia, A. Cuocolo, A. Pisani, E. Riccio, T. Di Risi, M. Ciccarelli, G. Santulli, D. Sorriento and G. Iaccarino. Experimental evidence and clinical implications of Warburg effect in the skeletal muscle of Fabry disease. iScience (Cell Press). 2023;26:106074. https://doi.org/10.1016/j.isci.2023.106074; PMID:36879801.

-I. Forzano, S. Wilson, A. Lombardi, S. S. Jankauskas, U. Kansakar, P. Mone, F. Varzideh and G. Santulli. SGLT2 inhibitors: An evidence-based update on cardiovascular implications. Expert Opin Investig Drugs. 2023;32:839-847. https://doi.org/10.1080/13543784.2023.2263354; PMID:37740906.

-H. Dridi, G. Santulli, L. Bahlouli, M. C. Miotto, G. Weninger and A. R. Marks. Mitochondrial calcium overload plays a causal role in oxidative stress in the failing heart. Biomolecules. 2023;13. https://doi.org/10.3390/biom13091409; PMID:37759809.

-F. Cailotto and G. Santulli. Wnt signaling in endocrine and metabolic disorders. Front Endocrinol. 2023;14:1254977. https://doi.org/10.3389/fendo.2023.1254977; PMID:37608791.

-R. Avvisato, P. Mone, S. S. Jankauskas, F. Varzideh, U. Kansakar, J. Gambardella, A. De Luca, A. Matarese and G. Santulli. miR-4432 targets FGFBP1 in human endothelial cells. Biology. 2023;12:459. https://doi.org/10.3390/biology12030459; PMID:36979151.

-R. Avvisato, S. S. Jankauskas, F. Varzideh, U. Kansakar, P. Mone and G. Santulli. Sortilin and hypertension. Curr Opin Nephrol Hypertens. 2023;32:134-140. https://doi.org/10.1097/mnh.0000000000000866; PMID:36683537.

-R. Avvisato, S. S. Jankauskas and G. Santulli. Istaroxime and beyond: New therapeutic strategies to specifically activate SERCA and treat heart failure. J Pharmacol Exp Ther. 2023;384:227-230. https://doi.org/10.1124/jpet.122.001446; PMID:36581352. [Journal Cover]

-R. Avvisato, I. Forzano, F. Varzideh, P. Mone and G. Santulli. A machine learning model identifies a functional connectome signature that predicts blood pressure levels: Imaging insights from a large population of 35 882 patients. Cardiovasc Res. 2023;119:1458-1460. https://doi.org/10.1093/cvr/cvad065; PMID:37093975.

-S. Wilson, P. Mone, U. Kansakar, S. S. Jankauskas, K. Donkor, A. Adebayo, F. Varzideh, M. Eacobacci, J. Gambardella, A. Lombardi and G. Santulli. Diabetes and restenosis. Cardiovasc Diabetol. 2022;21:23. https://doi.org/10.1186/s12933-022-01460-5; PMID:35164744.

-F. Varzideh, P. Mone and G. Santulli. Bioengineering strategies to create 3d cardiac constructs from human induced pluripotent stem cells. Bioengineering. 2022;9. https://doi.org/10.3390/bioengineering9040168; PMID:35447728.

-F. Varzideh, U. Kansakar, S. S. Jankauskas and G. Santulli. Aprocitentan: New insights. Front Cardiovasc Med. 2022;9:1093406. https://doi.org/10.3389/fcvm.2022.1093406; PMID:36620614.

-F. Varzideh, U. Kansakar, K. Donkor, S. Wilson, S. S. Jankauskas, P. Mone, X. Wang, A. Lombardi and G. Santulli. Cardiac remodeling after myocardial infarction: Functional contribution of microRNAs to inflammation and fibrosis. Front Cardiovasc Med. 2022;9:863238. https://doi.org/10.3389/fcvm.2022.863238; PMID:35498051.

-V. Trimarco, R. Izzo, A. Zanforlin, F. Tursi, F. Scarpelli, P. Santus, A. Pennisi, G. Pelaia, C. Mussi, S. Mininni, N. Messina, G. Marazzi, M. Maniscalco, M. Mallardo, G. Fazio, A. Diana, M. Capra Marzani, T. Aloè, P. Mone, B. Trimarco and G. Santulli. Endothelial dysfunction in long- COVID: New insights from the nationwide multicenter LINCOLN study. Pharmacol Res. 2022;185:106486. https://doi.org/10.1016/j.phrs.2022.106486; PMID:36206959.

-V. Trimarco, R. Izzo, C. Morisco, P. Mone, M. Virginia Manzi, A. Falco, D. Pacella, P. Gallo, M. Lembo, G. Santulli* (*Corresponding Author), and B. Trimarco. High HDL (high-density lipoprotein) cholesterol increases cardiovascular risk in hypertensive patients. Hypertension. 2022;79:2355-2363. https://doi.org/10.1161/hypertensionaha.122.19912; PMID:35968698. [Journal Cover and interview to Prof. Santulli published in Scientific American]

-V. Trimarco, R. Izzo, P. Mone, B. Trimarco and G. Santulli. Targeting endothelial dysfunction and oxidative stress in long-COVID. Pharmacological Research. 2022;184:106451. https://doi.org/10.1016/j.phrs.2022.106451; PMID:36108875.

-F. Varzideh, S. S. Jankauskas, U. Kansakar, P. Mone, J. Gambardella and G. Santulli. Sortilin drives hypertension by modulating sphingolipid/ceramide homeostasis and by triggering oxidative stress. J Clin Invest. 2022;132. https://doi.org/10.1172/jci156624; PMID:35104807.

-G. Santulli, X. Wang and P. Mone. Updated acc/aha/hfsa 2022 guidelines on heart failure: What is new? From epidemiology to clinical management. Eur Heart J Cardiovasc Pharmacother. 2022;8:e23-e24. https://doi.org/10.1093/ehjcvp/pvac029; PMID:35460242.

-G. Santulli, V. Trimarco, B. Trimarco and R. Izzo. Beneficial effects of Vitamin C and L-Arginine in the treatment of post-acute sequelae of COVID-19. Pharmacol Res. 2022;185:106479. https://doi.org/10.1016/j.phrs.2022.106479; PMID:36191881.

-G. Santulli and P. Mone. In permanent af with narrow QRS, AV junction ablation + CRT vs. Rate-control drug therapy reduced mortality. Ann Intern Med. 2022;175:Jc21. https://doi.org/10.7326/j21-0016; PMID:35099986. [Invited commentary on “AV junction ablation and cardiac resynchronization for patients with permanent atrial fibrillation and narrow QRS: the APAF-CRT mortality trial” Eur Heart J. 2021;42(46):4731-4739].

-G. Santulli, S. Frullone, M. Morgante, G. Macina, A. Pansini, J. Gambardella, A. Lombardi and P. Mone. Response to comment on mone et al. Empagliflozin improves cognitive impairment in frail older adults with type 2 diabetes and heart failure with preserved ejection fraction. Diabetes care 2022;45:1247-1251. Diabetes Care. 2022;45:e151-e152. https://doi.org/10.2337/dci22-0025; PMID:36150055.

-G. Santulli. Tirzepatide versus semaglutide once weekly in type 2 diabetes. N Engl J Med. 2022;386:e17. https://doi.org/10.1056/NEJMc2114590; PMID:35172066.

-DA. Raptis, A. Raptis, P. Tinguely, T. Mettler, PA. Clavien, M. Zuber, M. Lesurtel, R. Graf, SR. Abidi, D. Ferraro, S. Novelli, S. Leung, A. Palma, T. Schütz, G. Santulli, et al. (Authorships.org Collaborative). A platform (authorships.Org) for the objective qualification and order of academic authorship in medical and science journals: Development and evaluation study using the design science research methodology. JMIR Form Res. 2022;6:e34258. https://doi.org/10.2196/34258; PMID:35298392.

-P. Paolisso, L. Bergamaschi, G. Santulli, E. Gallinoro, A. Cesaro, F. Gragnano, C. Sardu, N. Mileva, A. Foà, M. Armillotta, A. Sansonetti, S. Amicone, A. Impellizzeri, G. Casella, C. Mauro, D. Vassilev, R. Marfella, P. Calabrò, E. Barbato and C. Pizzi. Infarct size, inflammatory burden, and admission hyperglycemia in diabetic patients with acute myocardial infarction treated with SGLT2-inhibitors: A multicenter international registry. Cardiovasc Diabetol. 2022;21:77. https://doi.org/10.1186/s12933-022-01506-8; PMID:35570280.

-A. Pansini, A. Lombardi, M. Morgante, S. Frullone, A. Marro, M. Rizzo, G. Martinelli, E. Boccalone, A. De Luca, G. Santulli and P. Mone. Hyperglycemia and physical impairment in frail hypertensive older adults. Front Endocrinol. 2022;13:831556. https://doi.org/10.3389/fendo.2022.831556; PMID:35498439.

-P. Mone, F. Varzideh, U. Kansakar, C. Infante, A. Lombardi, A. de Donato, S. Frullone and G. Santulli. Omega-3 fatty acids coordinate glucose and lipid metabolism in diabetic patients. Lipids Health Dis. 2022;21:31. https://doi.org/10.1186/s12944-022-01642-w; PMID:35337345.

-P. Mone, F. Varzideh, S. S. Jankauskas, A. Pansini, A. Lombardi, S. Frullone and G. Santulli. SGLT2 inhibition via empagliflozin improves endothelial function and reduces mitochondrial oxidative stress: Insights from frail hypertensive and diabetic patients. Hypertension. 2022;79:1633-1643. https://doi.org/10.1161/hypertensionaha.122.19586; PMID:35703100. [Featured on the Cover]

-P. Mone, B. Trimarco and G. Santulli. Aspirin, noacs, warfarin: Which is the best choice to tackle cognitive decline in elderly patients? Insights from the GIRAF and ASCEND-dementia trials presented at the AHA 2021. Eur Heart J Cardiovasc Pharmacother. 2022;8:E7-e8. https://doi.org/10.1093/ehjcvp/pvab081; PMID:34849683.

-P. Mone, A. Pansini, F. Varzideh, A. de Donato, S. S. Jankauskas and G. Santulli. Exosome-mediated angiogenesis underlies lvad-induced bleeding in patients with end-stage heart failure. JACC Basic Transl Sci. 2022;7:262-264. https://doi.org/10.1016/j.jacbts.2022.01.011; PMID:35411327.

-P. Mone, A. Pansini, S. S. Jankauskas, F. Varzideh, U. Kansakar, A. Lombardi, V. Trimarco, S. Frullone and G. Santulli. L-Arginine improves cognitive impairment in hypertensive frail older adults. Front Cardiovasc Med. 2022;9:868521. https://doi.org/10.3389/fcvm.2022.868521; PMID:35498050.

-P. Mone, A. Pansini, S. Frullone, A. de Donato, V. Buonincontri, P. De Blasiis, A. Marro, M. Morgante, A. De Luca and G. Santulli. Physical decline and cognitive impairment in frail hypertensive elders during COVID-19. Eur J Intern Med. 2022;99:89-92. https://doi.org/10.1016/j.ejim.2022.03.012; PMID:35300886.

-P. Mone, A. Pansini, F. Calabrò, S. De Gennaro, M. Esposito, P. Rinaldi, A. Colin, F. Minicucci, A. Coppola, S. Frullone and G. Santulli. Global cognitive function correlates with p-wave dispersion in frail hypertensive older adults. J Clin Hypertens (Greenwich). 2022;24:638-643. https://doi.org/10.1111/jch.14439; PMID:35229449.

-P. Mone, M. Morgante, A. Pansini, S. S. Jankauskas, M. Rizzo, A. Lombardi, S. Frullone and G. Santulli. Effects of insulin resistance on mitochondrial (dys)function. Atherosclerosis. 2022;341:52-54. https://doi.org/10.1016/j.atherosclerosis.2021.11.026; PMID:34903382.

-P. Mone, A. Lombardi, J. Gambardella, A. Pansini, G. Macina, M. Morgante, S. Frullone and G. Santulli. Empagliflozin improves cognitive impairment in frail older adults with type 2 diabetes and heart failure with preserved ejection fraction. Diabetes Care. 2022;45:1247-1251. https://doi.org/10.2337/dc21-2434; PMID:35287171.

-P. Mone, U. Kansakar, F. Varzideh, E. Boccalone, A. Lombardi, A. Pansini and G. Santulli. Epidemiology of obstructive sleep apnea: What is the contribution of hypertension and arterial stiffness? J Clin Hypertens (Greenwich). 2022;24:395-397. https://doi.org/10.1111/jch.14426; PMID:35156753.

-P. Mone, R. Izzo, G. Marazzi, M. V. Manzi, P. Gallo, G. Campolongo, L. Cacciotti, D. Tartaglia, G. Caminiti, F. Varzideh, G. Santulli and V. Trimarco. L-arginine enhances the effects of cardiac rehabilitation on physical performance: New insights for managing cardiovascular patients during the COVID-19 pandemic. J Pharmacol Exp Ther. 2022;381:197-203. https://doi.org/10.1124/jpet.122.001149; PMID:35339987.

-P. Mone, J. Gambardella, A. Pansini, G. Martinelli, F. Minicucci, C. Mauro and G. Santulli. Cognitive dysfunction correlates with physical impairment in frail patients with acute myocardial infarction. Aging Clin Exp Res. 2022;34:49-53. https://doi.org/10.1007/s40520-021-01897-w; PMID:34101155.

-P. Mone, J. Gambardella, A. Lombardi, A. Pansini, S. De Gennaro, A. L. Leo, M. Famiglietti, A. Marro, M. Morgante, S. Frullone, A. De Luca and G. Santulli. Correlation of physical and cognitive impairment in diabetic and hypertensive frail older adults. Cardiovasc Diabetol. 2022;21:10. https://doi.org/10.1186/s12933-021-01442-z; PMID:35045834.

-P. Mone, A. de Donato, F. Varzideh, U. Kansakar, S. S. Jankauskas, A. Pansini and G. Santulli. Functional role of miR-34a in diabetes and frailty. Front Aging. 2022;3:949924. https://doi.org/10.3389/fragi.2022.949924; PMID:35923683.

-U. Kansakar, F. Varzideh, P. Mone, S. S. Jankauskas and G. Santulli. Functional role of microRNAs in regulating cardiomyocyte death. Cells. 2022;11. https://doi.org/10.3390/cells11060983; PMID:35326433.

-U. Kansakar, J. Gambardella, F. Varzideh, R. Avvisato, S. S. Jankauskas, P. Mone, A. Matarese and G. Santulli. miR-142 targets TIM-1 in human endothelial cells: Potential implications for stroke, COVID-19, zika, ebola, dengue, and other viral infections. Int J Mol Sci. 2022;23. https://doi.org/10.3390/ijms231810242; PMID:36142146.

-S. S. Jankauskas, P. Mone and G. Santulli. From resveratrol to iside11: How to activate sirt1 and improve endothelial function? New therapeutic insights for methylenetetrahydrofolate reductase deficiency. Cell Mol Life Sci. 2022;79:451. https://doi.org/10.1007/s00018-022-04484-y; PMID:35895130.

-S. Jankauskas, U. Kansakar, A. De Donato, P. Mone, F. Varzideh and G. Santulli. Parkin controls cardiac function in obesity by regulating mitochondrial calcium uptake. JACC Basic Transl Sci. 2022;7:797-799. https://doi.org/10.1016/j.jacbts.2022.04.015; PMID:36061335.

-R. Izzo, V. Trimarco, P. Mone, T. Aloè, M. Capra Marzani, A. Diana, G. Fazio, M. Mallardo, M. Maniscalco, G. Marazzi, N. Messina, S. Mininni, C. Mussi, G. Pelaia, A. Pennisi, P. Santus, F. Scarpelli, F. Tursi, A. Zanforlin, G. Santulli* (*Corresponding Author),  and B. Trimarco. Combining L-Arginine with Vitamin C improves long-COVID symptoms: The LINCOLN survey. Pharmacol Res. 2022;183:106360. https://doi.org/10.1016/j.phrs.2022.106360; PMID:35868478.

-J. Gambardella, S. S. Jankauskas, S. L. D'Ascia, C. Sardu, A. Matarese, F. Minicucci, P. Mone and G. Santulli. Glycation of Ryanodine Receptor in circulating lymphocytes predicts the response to cardiac resynchronization therapy. J Heart Lung Transplant. 2022;41:438-441. https://doi.org/10.1016/j.healun.2021.12.008; PMID:35042640. [With Editorial Commentary]

-I. Forzano, F. Varzideh, R. Avvisato, S. S. Jankauskas, P. Mone and G. Santulli. Tirzepatide: A systematic update. Int J Mol Sci. 2022;23. https://doi.org/10.3390/ijms232314631; PMID:36498958.

-I. Forzano, P. Mone, F. Varzideh, S. S. Jankauskas, U. Kansakar, A. De Luca and G. Santulli. The selective aldosterone synthase inhibitor baxdrostat significantly lowers blood pressure in patients with resistant hypertension. Front Endocrinol. 2022;13:1097968. https://doi.org/10.3389/fendo.2022.1097968; PMID:36568122.

-I. Forzano, P. Mone, G. Mottola, U. Kansakar, L. Salemme, A. De Luca, T. Tesorio, F. Varzideh and G. Santulli. Efficacy of the new inotropic agent istaroxime in acute heart failure. J Clin Med. 2022;11. https://doi.org/10.3390/jcm11247503; PMID:36556120.

-H. Dridi, G. Santulli, J. Gambardella, S. S. Jankauskas, Q. Yuan, J. Yang, S. Reiken, X. Wang, A. Wronska, X. Liu, A. Lacampagne and A. R. Marks. IP3 Receptor orchestrates maladaptive vascular responses in heart failure. J Clin Invest. 2022;132. https://doi.org/10.1172/jci152859; PMID:35166236.

-A. Cesaro, F. Gragnano, P. Paolisso, L. Bergamaschi, E. Gallinoro, C. Sardu, N. Mileva, A. Foà, M. Armillotta, A. Sansonetti, S. Amicone, A. Impellizzeri, G. Esposito, N. Morici, J. A. Oreglia, G. Casella, C. Mauro, D. Vassilev, N. Galie, G. Santulli, C. Pizzi, E. Barbato, P. Calabrò and R. Marfella. In-hospital arrhythmic burden reduction in diabetic patients with acute myocardial infarction treated with SGLT2-inhibitors: Insights from the SGLT2-i AMI protect study. Front Cardiovasc Med. 2022;9:1012220. https://doi.org/10.3389/fcvm.2022.1012220; PMID:36237914.

-H. Bonnet, B. Bogard, F. Hubé, M. Ilieva, S. Uchida, MA. Ariza-Mateos, A. Serganov, B. Pardini, A. Naccarati, G. Santulli, F. Varzideh, H. Xiao and PKT. Shiu. The non-coding RNA journal club: Highlights on recent papers-11. Noncoding RNA. 2022;8. https://doi.org/10.3390/ncrna8030031; PMID:35645338.

-S. Wilson, P. Mone, S. S. Jankauskas, J. Gambardella and G. Santulli. Chronic kidney disease: Definition, updated epidemiology, staging, and mechanisms of increased cardiovascular risk. J Clin Hypertens (Greenwich). 2021;23:831-834. https://doi.org/10.1111/jch.14186; PMID:33455061.

-F. Varzideh, U. Kansakar and G. Santulli. SGLT2 inhibitors in cardiovascular medicine. Eur Heart J Cardiovasc Pharmacother. 2021;7:e67-e68. https://doi.org/10.1093/ehjcvp/pvab039; PMID:33964138.

-F. Varzideh, U. Kansakar, SS. Jankauskas, J. Gambardella and G. Santulli. Cardiovascular endocrinology: Evolving concepts and updated epidemiology of relevant diseases. Front Endocrinol. 2021;12:772876. https://doi.org/10.3389/fendo.2021.772876; PMID:34675888.

-X. H. Tang, J. Gambardella, S. Jankauskas, X. Wang, G. Santulli, L. J. Gudas and R. Levi. A retinoic acid receptor β₂ agonist improves cardiac function in a heart failure model. J Pharmacol Exp Ther. 2021;379:182-190. https://doi.org/10.1124/jpet.121.000806; PMID:34389654. [Journal Cover]

-C. Sardu, M. Massetti, N. Testa, L. D. Martino, G. Castellano, F. Turriziani, F. C. Sasso, M. Torella, M. De Feo, G. Santulli, G. Paolisso and R. Marfella. Effects of sodium-glucose transporter 2 inhibitors (SGLT2-i) in patients with ischemic heart disease treated by coronary artery bypass grafting via miecc: Inflammatory burden, and clinical outcomes at 5 years of follow-up. Front Pharmacol. 2021;12:777083. https://doi.org/10.3389/fphar.2021.777083; PMID:34867407.

-G. Santulli, G. Monaco, V. Parra and G. Morciano. Mitochondrial remodeling and dynamic inter-organellar contacts in cardiovascular physiopathology. Front Cell Dev Biol. 2021;9:679725. https://doi.org/10.3389/fcell.2021.679725; PMID:33996837.

-G. Santulli, SS. Jankauskas and J. Gambardella. Inclisiran: A new milestone on the pcsk9 road to tackle cardiovascular risk. Eur Heart J Cardiovasc Pharmacother. 2021;7:e11-e12. https://doi.org/10.1093/ehjcvp/pvab014; PMID:33655296.

-G. Santulli. In patients with early AF and CV conditions, early rhythm-control therapy vs. Usual care reduced CV events at 5 years. Ann Intern Med. 2021;174:Jc6. https://doi.org/10.7326/acpj202101190-006; PMID:33395332. [Invited commentary on “Early Rhythm-Control Therapy in Patients with Atrial Fibrillation” N Engl J Med. 2020;383(14):1305-1316].

-N. Renwick, A. El-Osta, I. Salamon, E. Broseghini, M. Ferracin, L. Poliseno, S. S. Jankauskas, G. Santulli, H. Xiao, P. K. T. Shiu, S. Roy and A. Goel. The non-coding RNA journal club: Highlights on recent papers-9. Noncoding RNA. 2021;7. https://doi.org/10.3390/ncrna7030058; PMID:34564320.

-P. Mone, J. Gambardella, X. Wang, S. S. Jankauskas, A. Matarese and G. Santulli. miR-24 targets the transmembrane glycoprotein neuropilin-1 in human brain microvascular endothelial cells. Noncoding RNA. 2021;7. https://doi.org/10.3390/ncrna7010009; PMID:33540664.

-P. Mone, J. Gambardella, A. Pansini, M. Rizzo, C. Mauro, F. Minicucci and G. Santulli. Impact of thrombus aspiration in frail stemi patients. Aging Clin Exp Res. 2021;33:3081-3089. https://doi.org/10.1007/s40520-021-01848-5; PMID:33817772.

-P. Mone, J. Gambardella, A. Pansini, A. de Donato, G. Martinelli, E. Boccalone, A. Matarese, S. Frullone and G. Santulli. Cognitive impairment in frail hypertensive elderly patients: Role of hyperglycemia. Cells. 2021;10. https://doi.org/10.3390/cells10082115; PMID:34440883.

-P. Mone, J. Gambardella, F. Minicucci, A. Lombardi, C. Mauro and G. Santulli. Hyperglycemia drives stent restenosis in stemi patients. Diabetes Care. 2021;44:e192-e193. https://doi.org/10.2337/dc21-0939; PMID:34531311.

-U. Kansakar, F. Varzideh, S. S. Jankauskas, J. Gambardella, B. Trimarco and G. Santulli. Advances in the understanding of excitation-contraction coupling: The pulsing quest for drugs against heart failure and arrhythmias. Eur Heart J Cardiovasc Pharmacother. 2021;7:e91-e93. https://doi.org/10.1093/ehjcvp/pvab069; PMID:34498676.

-U. Kansakar, S. S. Jankauskas, J. Gambardella and G. Santulli. Targeting the phenotypic switch of vascular smooth muscle cells to tackle atherosclerosis. Atherosclerosis. 2021;324:117-120. https://doi.org/10.1016/j.atherosclerosis.2021.03.034; PMID:33832772.

-S. S. Jankauskas, M. B. Morelli, J. Gambardella, A. Lombardi and G. Santulli. Thyroid hormones regulate both cardiovascular and renal mechanisms underlying hypertension. J Clin Hypertens (Greenwich). 2021;23:373-381. https://doi.org/10.1111/jch.14152; PMID:33377271.

-S. S. Jankauskas, U. Kansakar, F. Varzideh, S. Wilson, P. Mone, A. Lombardi, J. Gambardella and G. Santulli. Heart failure in diabetes. Metabolism. 2021;125:154910. https://doi.org/10.1016/j.metabol.2021.154910; PMID:34627874.

-S. S. Jankauskas, J. Gambardella, C. Sardu, A. Lombardi and G. Santulli. Functional role of miR-155 in the pathogenesis of diabetes mellitus and its complications. Noncoding RNA. 2021;7. https://doi.org/10.3390/ncrna7030039; PMID:34287359.

-J. Gambardella and G. Santulli. What is linking COVID-19 and endothelial dysfunction? Updates on nanomedicine and bioengineering from the 2020 AHA scientific sessions. Eur Heart J Cardiovasc Pharmacother. 2021;7:e2-e3. https://doi.org/10.1093/ehjcvp/pvaa145; PMID:33377481.

-J. Gambardella, M. B. Morelli, X. Wang, V. Castellanos, P. Mone and G. Santulli. The discovery and development of IP3 receptor modulators: An update. Expert Opin Drug Discov. 2021;16:709-718. https://doi.org/10.1080/17460441.2021.1858792; PMID:33356639.

-J. Gambardella, A. Fiordelisi, L. Spigno, L. Boldrini, G. Lungonelli, E. Di Vaia, G. Santulli, D. Sorriento, F. A. Cerasuolo, V. Trimarco and G. Iaccarino. Effects of chronic supplementation of l-arginine on physical fitness in water polo players. Oxid Med Cell Longev. 2021;2021:6684568. https://doi.org/10.1155/2021/6684568; PMID:33815657.

-J. Gambardella, A. Coppola, R. Izzo, G. Fiorentino, B. Trimarco and G. Santulli. Role of endothelial miR-24 in COVID-19 cerebrovascular events. Critical Care. 2021;25:306. https://doi.org/10.1186/s13054-021-03731-1; PMID:34433473.

-J. Gambardella, V. Castellanos and G. Santulli. Standardizing translational microbiome studies and metagenomic analyses. Cardiovasc Res. 2021;117:640-642. https://doi.org/10.1093/cvr/cvaa175; PMID:32569375.

-G. Fiorentino, A. Coppola, R. Izzo, A. Annunziata, M. Bernardo, A. Lombardi, V. Trimarco, G. Santulli and B. Trimarco. Effects of adding L-Arginine orally to standard therapy in patients with COVID-19: A randomized, double-blind, placebo-controlled, parallel-group trial. Results of the first interim analysis. Lancet - eClinicalMedicine. 2021;40:101125. https://doi.org/10.1016/j.eclinm.2021.101125; PMID:34522871.

-A. Adebayo, F. Varzideh, S. Wilson, J. Gambardella, M. Eacobacci, S. S. Jankauskas, K. Donkor, U. Kansakar, V. Trimarco, P. Mone, A. Lombardi and G. Santulli. L-arginine and COVID-19: An update. Nutrients. 2021;13. https://doi.org/10.3390/nu13113951; PMID:34836206.

-X. Wang, M. B. Morelli, A. Matarese, C. Sardu and G. Santulli. Cardiomyocyte-derived exosomal microRNA-92a mediates post-ischemic myofibroblast activation both in vitro and ex vivo. ESC Heart Fail. 2020;7:284-288. https://doi.org/10.1002/ehf2.12584; PMID:31981320.

-C. Sardu, G. Santulli, G. Guerra, M. C. Trotta, M. Santamaria, C. Sacra, N. Testa, V. Ducceschi, G. Gatta, M. Amico, F. C. Sasso, G. Paolisso and R. Marfella. Modulation of SERCA in patients with persistent atrial fibrillation treated by epicardial thoracoscopic ablation: The CAMAF study. J Clin Med. 2020;9. https://doi.org/10.3390/jcm9020544; PMID:32079238.

-G. Santulli. In AF and stable CAD, rivaroxaban reduced cardiovascular events and mortality more than rivaroxaban plus an antiplatelet. Ann Intern Med. 2020;172:Jc6. https://doi.org/10.7326/acpj202001210-006; PMID:31958820. [Invited commentary on “Antithrombotic Therapy for Atrial Fibrillation with Stable Coronary Disease” N Engl J Med. 2019;381(12):1103-1113.]

-C. Sardu, R. Marfella, P. Maggi, V. Messina, P. Cirillo, V. Codella, J. Gambardella, A. Sardu, G. Gatta, G. Santulli and G. Paolisso. Implications of ABO blood group in hypertensive patients with COVID-19. BMC Cardiovasc Disord. 2020;20:373. https://doi.org/10.1186/s12872-020-01658-z; PMID:32799852.

-C. Sardu, J. Gambardella, M. B. Morelli, X. Wang, R. Marfella and G. Santulli. Hypertension, thrombosis, kidney failure, and diabetes: Is COVID-19 an endothelial disease? A comprehensive evaluation of clinical and basic evidence. J Clin Med. 2020;9:1417. https://doi.org/10.3390/jcm9051417; PMID:32403217. [>600 citations]

-M. B. Morelli, G. Santulli and J. Gambardella. Calcium supplements: Good for the bone, bad for the heart? A systematic updated appraisal. Atherosclerosis. 2020;296:68-73. https://doi.org/10.1016/j.atherosclerosis.2020.01.008; PMID:32033778.

-M. Morelli, J. Gambardella, V. Castellanos, V. Trimarco and G. Santulli. Vitamin C and cardiovascular disease: An update. Antioxidants. 2020;9. https://doi.org/10.3390/antiox9121227; PMID:33287462.

-MB. Morelli, C. Chavez and G. Santulli. Angiopoietin-like proteins as therapeutic targets for cardiovascular disease: Focus on lipid disorders. Expert Opin Ther Targets. 2020;24:79-88. https://doi.org/10.1080/14728222.2020.1707806; PMID:31856617.

-A. Matarese, J. Gambardella, C. Sardu and G. Santulli. miR-98 regulates TMPRSS2 expression in human endothelial cells: Key implications for COVID-19. BioMedicines. 2020;8:462. https://doi.org/10.3390/biomedicines8110462; PMID:33143053.

-A. Matarese, J. Gambardella, A. Lombardi, X. Wang and G. Santulli. miR-7 regulates glp-1-mediated insulin release by targeting β-arrestin 1. Cells. 2020;9. https://doi.org/10.3390/cells9071621; PMID:32640511.

-J. Gambardella, X. J. Wang, J. Ferrara, M. B. Morelli and G. Santulli. Cardiac bin1 replacement therapy ameliorates inotropy and lusitropy in heart failure by regulating calcium handling. JACC Basic Transl Sci. 2020;5:579-581. https://doi.org/10.1016/j.jacbts.2020.03.018; PMID:32614937.

-J. Gambardella, X. Wang, P. Mone, W. Khondkar and G. Santulli. Genetics of adrenergic signaling drives coronary artery calcification. Atherosclerosis. 2020;310:88-90. https://doi.org/10.1016/j.atherosclerosis.2020.07.025; PMID:32863027.

-J. Gambardella, D. Sorriento, M. Bova, M. Rusciano, S. Loffredo, X. Wang, A. Petraroli, L. Carucci, I. Mormile, M. Oliveti, M. Bruno Morelli, A. Fiordelisi, G. Spadaro, P. Campiglia, M. Sala, B. Trimarco, G. Iaccarino, G. Santulli and M. Ciccarelli. Role of endothelial G protein-coupled receptor kinase 2 (GRK2) in angioedema. Hypertension. 2020;76:1625-1636. https://doi.org/10.1161/hypertensionaha.120.15130; PMID:32895019.

-G. Santulli. In acute HF, intensive and sustained vasodilation did not reduce a composite of death or hf readmission at 180 days. Annals of Internal Medicine. 2020;172:Jc54. https://doi.org/10.7326/acpj202005190-054; PMID:32422099. [Invited commentary on “Effect of a Strategy of Comprehensive Vasodilation vs Usual Care on Mortality and Heart Failure Rehospitalization Among Patients with Acute Heart Failure: The GALACTIC Randomized Clinical Trial.” JAMA. 322(23):2292-2302].

-J. Gambardella, M. B. Morelli, X. J. Wang and G. Santulli. Pathophysiological mechanisms underlying the beneficial effects of physical activity in hypertension. J Clin Hypertens. 2020;22:291-295. https://doi.org/10.1111/jch.13804; PMID:31955526.

-J. Gambardella, A. Lombardi and G. Santulli. Metabolic flexibility of mitochondria plays a key role in balancing glucose and fatty acid metabolism in the diabetic heart. Diabetes. 2020;69:2054-2057. https://doi.org/10.2337/dbi20-0024; PMID:32958606.

-J. Gambardella, A. Lombardi, M. B. Morelli, J. Ferrara and G. Santulli. Inositol 1,4,5-trisphosphate receptors in human disease: A comprehensive update. J Clin Med. 2020;9. https://doi.org/10.3390/jcm9041096; PMID:32290556.

-G. Santulli, M. Morelli, J. Gambardella. Is Endothelial Dysfunction the Concealed Cornerstone of COVID-19? BMJ. 2020; e-letter. https://www.bmj.com/content/368/bmj.m1091/rr-13

-J. Gambardella, W. Khondkar, M. B. Morelli, X. Wang, G. Santulli and V. Trimarco. Arginine and endothelial function. BioMedicines. 2020;8;277. https://doi.org/10.3390/biomedicines8080277; PMID:32781796.

-J. Gambardella, A. Fiordelisi, G. Santulli, M. Ciccarelli, F. A. Cerasuolo, M. Sala, E. Sommella, P. Campiglia, M. Illario, G. Iaccarino and D. Sorriento. Exploiting GRK2 inhibition as a therapeutic option in experimental cancer treatment: Role of p53-induced mitochondrial apoptosis. Cancers. 2020;12:3530. https://doi.org/10.3390/cancers12123530; PMID:33256128.

-D. Amgalan, T. P. Garner, R. Pekson, X. F. Jia, M. Yanamandala, V. Paulino, F. G. Liang, J. J. Corbalan, J. Lee, Y. Chen, G. S. Karagiannis, L. R. Sanchez, H. Liang, S. R. Narayanagari, K. Mitchell, A. Lopez, V. Margulets, M. Scarlata, G. Santulli, A. Asnani, R. T. Peterson, R. B. Hazan, J. S. Condeelis, M. H. Oktay, U. Steidl, L. A. Kirshenbaum, E. Gavathiotis and R. N. Kitsis. A small-molecule allosteric inhibitor of bax protects against doxorubicin-induced cardiomyopathy. Nature Cancer. 2020;1:315-328. https://doi.org/10.1038/s43018-020-0039-1; PMID:32776015.

-M. H. Al-Mallah, F. Hyafil and G. Santulli. No pleotropic effects of linagliptin on atherosclerotic plaques: Case closed. Atherosclerosis. 2020;305:61-63. https://doi.org/10.1016/j.atherosclerosis.2020.05.009; PMID:32561072.

- J. Gambardella, C. Sardu, G. Santulli. COVID-19 and endothelial dysfunction. JAMA. 2020; e-letter. https://jamanetwork.com/journals/jama/fullarticle/2765184.

-H. Xiao, P. K. T. Shiu, M. Gabryleska, S. J. Conn, A. Dey, K. Chakrabarti, M. Regouc, M. Pichler, U. A. V. Ørom, G. Santulli, S. Nishiwada, A. Goel, V. Nagarajan, L. Timmons, S. K. Alahari, N. Laprovitera, M. Ferracin, P. Hu and H. Jin. The non-coding RNA journal club: Highlights on recent papers-7. Noncoding RNA. 2019;5. https://doi.org/10.3390/ncrna5020040; PMID:31212658.

-J. Shu and G. Santulli. Heparanase in health and disease: The neglected housekeeper of the cell? Atherosclerosis. 2019;283:124-126. https://doi.org/10.1016/j.atherosclerosis.2019.01.017; PMID:30745229.

-J. Shu, A. Matarese and G. Santulli. Diabetes, body fat, skeletal muscle, and hypertension: The ominous chiasmus? J Clin Hypertens. 2019;21:239-242. https://doi.org/10.1111/jch.13453; PMID:30525276.

-C. Sardu, C. De Lucia, M. Wallner and G. Santulli. Diabetes mellitus and its cardiovascular complications: New insights into an old disease. J Diabetes Res. 2019;2019:1905194. https://doi.org/10.1155/2019/1905194; PMID:31236416.

-G. Santulli, V. Pascale, R. Finelli, V. Visco, R. Giannotti, A. Massari, C. Morisco, M. Ciccarelli, M. Illario, G. Iaccarino and E. Coscioni. We are what we eat: Impact of food from short supply chain on metabolic syndrome. J Clin Med. 2019;8. https://doi.org/10.3390/jcm8122061; PMID:31771147.

-G. Santulli and M. H. Al-Mallah. Pre-eclampsia and future cardiovascular diseases: How to assess the risk? Atherosclerosis. 2019;290:136-137. https://doi.org/10.1016/j.atherosclerosis.2019.07.004; PMID:31300163.

-G. Santulli. Cardiovascular disease and diabetes. Front Endocrinol. 2019;10:314. https://doi.org/10.3389/fendo.2019.00314; PMID:31156559.

-G. Santulli. Safety in numbers: Identifying multiple targets for beta cell proliferation. Sci Transl Med. 2019;11. https://doi.org/10.1126/scitranslmed.aaw5312; PMID:31171952.

-G. Santulli. Catheter ablation did not reduce CV events and mortality more than drug therapy in symptomatic AF. Ann Intern Med. 2019;171:Jc8. https://doi.org/10.7326/acpj201907160-008; PMID:31307069.

-G. Santulli. Catheter ablation improved quality of life more than drug therapy at 1 y in symptomatic atrial fibrillation. Ann Intern Med. 2019;171:Jc10. https://doi.org/10.7326/acpj201907160-010; PMID:31307071. [Invited commentaries on “Effect of Catheter Ablation vs Medical Therapy on Quality of Life Among Patients with Atrial Fibrillation: The CABANA Randomized Clinical Trial” JAMA. 2019;321(13):1275-1285 and “Effect of Catheter Ablation vs Antiarrhythmic Medication on Quality of Life in Patients with Atrial Fibrillation: The CAPTAF Randomized Clinical Trial” JAMA. 2019;321(11):1059-1068].

-M. B. Morelli, X. Wang and G. Santulli. Functional role of gut microbiota and pcsk9 in the pathogenesis of diabetes mellitus and cardiovascular disease. Atherosclerosis. 2019;289:176-178. https://doi.org/10.1016/j.atherosclerosis.2019.07.023; PMID:31431286.

-M. B. Morelli, J. Shu, C. Sardu, A. Matarese and G. Santulli. Cardiosomal microRNAs are essential in post-infarction myofibroblast phenoconversion. Int J Mol Sci. 2019;21. https://doi.org/10.3390/ijms21010201; PMID:31892162.

-A. Matarese, C. Sardu, J. Shu and G. Santulli. Why is chronic obstructive pulmonary disease linked to atrial fibrillation? A systematic overview of the underlying mechanisms. Int J Cardiol. 2019;276:149-151. https://doi.org/10.1016/j.ijcard.2018.10.075; PMID:30446289.

-G. Santulli. In type 2 diabetes, intensive glucose control for 5.6 years did not differ from usual care for major CV events at 14 years. Ann Intern Med. 2019;171:Jc31. https://doi.org/10.7326/acpj201909170-031; PMID:31525765. [Invited commentary on “Intensive Glucose Control in Patients with Type 2 Diabetes - 15-Year Follow-up” N Engl J Med. 2019;380(23):2215-2224].

-H. Xiao, P. K. T. Shiu, J. Shu, G. Santulli, M. K. Gheybi, S. J. Conn, B. Bogard, F. Hubé, J. H. Taube, S. A. Mani, L. Song, G. A. Calin and S. Zhang. The non-coding RNA journal club: Highlights on recent papers-6. Noncoding RNA. 2018;4. https://doi.org/10.3390/ncrna4030023; PMID:30231579.

-D. Sorriento, G. Santulli, M. Ciccarelli, A. S. Maione, M. Illario, B. Trimarco and G. Iaccarino. The amino-terminal domain of GRK5 inhibits cardiac hypertrophy through the regulation of calcium-calmodulin dependent transcription factors. Int J Mol Sci. 2018;19. https://doi.org/10.3390/ijms19030861; PMID:29543709.

-J. Shu and G. Santulli. Update on peripheral artery disease: Epidemiology and evidence-based facts. Atherosclerosis. 2018;275:379-381. https://doi.org/10.1016/j.atherosclerosis.2018.05.033; PMID:29843915.

-G. Santulli, D. Lewis, A. des Georges, A. Marks and J. Frank. Ryanodine receptor structure and function in health and disease. Subcell Biochem. 2018;87:329-352. https://doi.org/10.1007/978-981-10-7757-9_11; PMID:29464565. [F1000 recommended article].

-G. Santulli. Overlooking cardiac dysfunction triggered by immune checkpoint inhibitors: Caution, trespassers will be ventilated. Sci Transl Med. 2018;10. https://doi.org/10.1126/scitranslmed.aat3888; PMID:31396365.

-G. Santulli. Cardioprotective effects of autophagy: Eat your heart out, heart failure! Sci Transl Med. 2018;10. https://doi.org/10.1126/scitranslmed.aau0462; PMID:29911692.

-G. Santulli. In diabetes with no CVD, aspirin reduced serious vascular events but increased major bleeding at 7.4 years. Annals of Internal Medicine. 2018;169:Jc67. https://doi.org/10.7326/acpjc-2018-169-12-067; PMID:30557420. [Invited commentary on "Effects of aspirin for primary prevention in persons with diabetes mellitus" NEJM. 2018;379:1529-39].

-G. Santulli. Endothelial cells: The heart attack of the clones. Sci Transl Med. 2018;10. https://doi.org/10.1126/scitranslmed.aar7529; PMID:29983858.

-G. Santulli. The lymphatic border patrol outwits inflammatory cells in myocardial infarction. Sci Transl Med. 2018;10. https://doi.org/10.1126/scitranslmed.aau7379; PMID:30774753.

-G. Santulli. Exosomal microRNA: The revolutionary endogenous innerspace nanotechnology. Sci Transl Med. 2018;10. https://doi.org/10.1126/scitranslmed.aav9141; PMID:30899414.

-G. Santulli. Stroke prevention: Learning from the master (and commander). Science Translational Medicine. 2018;10. https://doi.org/10.1126/scitranslmed.aav0340; PMID:31031885. [Invited commentary on “Rivaroxaban in patients with heart failure, sinus rhythm, and coronary disease” NEJM. 2018;379(14):1332-1342].

-A. Kushnir, G. Santulli, S. R. Reiken, E. Coromilas, S. J. Godfrey, D. L. Brunjes, P. C. Colombo, M. Yuzefpolskaya, S. I. Sokol, R. N. Kitsis and A. R. Marks. Ryanodine receptor calcium leak in circulating B-lymphocytes as a biomarker in heart failure. Circulation. 2018;138:1144-1154. https://doi.org/10.1161/circulationaha.117.032703; PMID:29593014. [F1000 recommended article].

-J. Gambardella, B. Trimarco, G. Iaccarino and G. Santulli. New insights in cardiac calcium handling and excitation-contraction coupling. Adv Exp Med Biol. 2018;1067:373-385. https://doi.org/10.1007/5584_2017_106; PMID:28956314.

-M. De Rosa and G. Santulli. Effectiveness of new generation drug-eluting stents in ostial right coronary artery lesions. Int J Cardiol. 2018;254:84-86. https://doi.org/10.1016/j.ijcard.2017.11.105; PMID:29407134.

-M. De Rosa, J. Gambardella, J. Shu and G. Santulli. Dietary fat is a key determinant in balancing mitochondrial dynamics in heart failure: A novel mechanism underlying the obesity paradox. Cardiovasc Res. 2018;114:925-927. https://doi.org/10.1093/cvr/cvy074; PMID:29579150.

-D. Sorriento, J. Gambardella, A. Fiordelisi, B. Trimarco, M. Ciccarelli, G. Iaccarino and G. Santulli. Mechanistic role of kinases in the regulation of mitochondrial fitness. Adv Exp Med Biol. 2017;982:521-528. https://doi.org/10.1007/978-3-319-55330-6_26; PMID:28551804.

-C. Sardu, G. Santulli, M. Santamaria, M. Barbieri, C. Sacra, P. Paolisso, F. D'Amico, N. Testa, I. Caporaso, G. Paolisso, R. Marfella and M. R. Rizzo. Effects of alpha lipoic acid on multiple cytokines and biomarkers and recurrence of atrial fibrillation within 1 year of catheter ablation. Am J Cardiol. 2017;119:1382-1386. https://doi.org/10.1016/j.amjcard.2017.01.040; PMID:28258730.

-G. Santulli, R. Nakashima, Q. Yuan and A. R. Marks. Intracellular calcium release channels: An update. J Physiol. 2017;595:3041-3051. https://doi.org/10.1113/jp272781; PMID:28303572.

-G. Santulli, D. R. Lewis and A. R. Marks. Physiology and pathophysiology of excitation-contraction coupling: The functional role of Ryanodine Receptor. J Muscle Res Cell Motil. 2017;38:37-45. https://doi.org/10.1007/s10974-017-9470-z; PMID:28653141.

-A. Lombardi, B. Trimarco, G. Iaccarino and G. Santulli. Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure. Cell Commun Signal. 2017;15:47. https://doi.org/10.1186/s12964-017-0203-0; PMID:29132395.

-A. Lombardi, J. Gambardella, X. L. Du, D. Sorriento, M. Mauro, G. Iaccarino, B. Trimarco and G. Santulli. Sirolimus induces depletion of intracellular calcium stores and mitochondrial dysfunction in pancreatic beta cells. Sci Rep. 2017;7:15823. https://doi.org/10.1038/s41598-017-15283-y; PMID:29158477.

-J. Gambardella, D. Sorriento, M. Ciccarelli, C. Del Giudice, A. Fiordelisi, L. Napolitano, B. Trimarco, G. Iaccarino and G. Santulli. Functional role of mitochondria in arrhythmogenesis. Adv Exp Med Biol. 2017;982:191-202. https://doi.org/10.1007/978-3-319-55330-6_10; PMID:28551788.

-J. Gambardella, C. Sardu, C. Sacra, C. Del Giudice and G. Santulli. Quit smoking to outsmart atherogenesis: Molecular mechanisms underlying clinical evidence. Atherosclerosis. 2017;257:242-245. https://doi.org/10.1016/j.atherosclerosis.2016.12.010; PMID:28108018.

-E. Cipolletta, C. Del Giudice, G. Santulli, B. Trimarco and G. Iaccarino. Opposite effects of β(2)-adrenoceptor gene deletion on insulin signaling in liver and skeletal muscle. Nutr Metab Cardiovasc Dis. 2017;27:615-623. https://doi.org/10.1016/j.numecd.2017.05.011; PMID:28684080.

-M. Ciccarelli, R. Finelli, N. Rivera, G. Santulli, R. Izzo, N. De Luca, F. Rozza, M. Ceccarelli, S. Pagnotta, F. Uliano, R. Tremigliozzi, G. Condorelli, V. Trimarco and G. Iaccarino. The possible role of chromosome x variability in hypertensive familiarity. J Hum Hypertens. 2017;31:37-42. https://doi.org/10.1038/jhh.2016.9; PMID:26911533.

-C. Achour, B. Bogard, F. Hubé, S. A. Mani, G. Santulli and J. H. Taube. Linking inflammation and beta cell death: the functional role of microRNA. Noncoding RNA. 2017;3. https://doi.org/10.3390/ncrna3020021; PMID:29657292.

-Q. Yuan, J. Yang, G. Santulli* (*co-First Authorship; Corresponding Author), S. R. Reiken, A. Wronska, M. M. Kim, B. W. Osborne, A. Lacampagne, Y. Yin and A. Marks. Maintenance of normal blood pressure is dependent on IP3R1-mediated regulation of enos. Proc Natl Acad Sci U S A (PNAS). 2016;113:8532-7. https://doi.org/10.1073/pnas.1608859113; PMID:27402766.

-C. Sardu, M. Santamaria, M. R. Rizzo, M. Barbieri, M. di Marino, G. Paolisso, G. Santulli and R. Marfella. Telemonitoring in heart failure patients treated by cardiac resynchronisation therapy with defibrillator (CRT-d): The TELECART study. Int J Clin Pract. 2016;70:569-76. https://doi.org/10.1111/ijcp.12823; PMID:27291327.

-G. Santulli and G. Iaccarino. Adrenergic signaling in heart failure and cardiovascular aging. Maturitas. 2016;93:65-72. https://doi.org/10.1016/j.maturitas.2016.03.022; PMID:27062709.

-G. Santulli. MicroRNAs and endothelial (dys) function. J Cell Physiol. 2016;231:1638-44. https://doi.org/10.1002/jcp.25276; PMID:26627535.

-G. Santulli. Dietary components and metabolic dysfunction: Translating preclinical studies into clinical practice. Nutrients. 2016;8. https://doi.org/10.3390/nu8100632; PMID:27754375.

-G. Santulli. Childhood obesity and education. Lancet Diabetes Endocrinol. 2016;4:957. https://doi.org/10.1016/s2213-8587(15)00517-3; PMID:26928651.

-S. Matecki, H. Dridi, B. Jung, N. Saint, S. R. Reiken, V. Scheuermann, S. Mrozek, G. Santulli, A. Umanskaya, B. J. Petrof, S. Jaber, A. R. Marks and A. Lacampagne. Leaky Ryanodine Receptors contribute to diaphragmatic weakness during mechanical ventilation. PNAS. 2016;113:9069-74. (Direct Submission) https://doi.org/10.1073/pnas.1609707113; PMID:27457930.

-D. Gautheret, J. H. Taube, S. A. Mani, G. Santulli, D. Cuerda-Gil, R. K. Slotkin, B. Zhang, Y. Wang, D. W. Salzman and J. B. Weidhaas. Microbiome and MicroRNA mediate the communication between gut and vasculature. Noncoding RNA. 2016;2. https://doi.org/10.3390/ncrna2030009; PMID:29657267.

-J. Gambardella and G. Santulli. Integrating diet and inflammation to calculate cardiovascular risk. Atherosclerosis. 2016;253:258-261. https://doi.org/10.1016/j.atherosclerosis.2016.08.041; PMID:27594541.

- G. Santulli. A leaky endoplasmic reticulum calcium channel impairs insulin secretion. JCI Impact 2015;May Issue:p10. Editor’s picks.

-W. Xie, G. Santulli* (*co-first Author), S. R. Reiken, Q. Yuan, B. W. Osborne, B. X. Chen and A. Marks. Mitochondrial oxidative stress promotes atrial fibrillation. Scientific Reports. 2015;5:11427. https://doi.org/10.1038/srep11427; PMID:26169582.

-A. Wronska, I. Kurkowska-Jastrzebska and G. Santulli. Application of micrornas in diagnosis and treatment of cardiovascular disease. Acta Physiol (Oxford). 2015;213:60-83. https://doi.org/10.1111/apha.12416; PMID:25362848.

-G. Santulli. A fleeting glimpse inside microRNA, epigenetics, and micropeptidomics. Adv Exp Med Biol. 2015;887:1-14. https://doi.org/10.1007/978-3-319-22380-3_1; PMID:26662983.

-D. Sorriento, G. Santulli, A. Franco, E. Cipolletta, L. Napolitano, J. Gambardella, I. Gomez-Monterrey, P. Campiglia, B. Trimarco, G. Iaccarino and M. Ciccarelli. Integrating GRK2 and NFkappaB in the pathophysiology of cardiac hypertrophy. J Cardiovasc Transl Res. 2015;8:493-502. https://doi.org/10.1007/s12265-015-9646-0; PMID:26224342.

-G. Santulli, W. Xie, S. R. Reiken and A. R. Marks. Mitochondrial calcium overload is a key determinant in heart failure. Proc Natl Acad Sci U S A (PNAS). 2015;112:11389-94. https://doi.org/10.1073/pnas.1513047112; PMID:26217001. [With Editorial Commentary by Jon Lederer; F1000 recommended article; Highly cited article (Thomson Reuters: Top 1% in Biomedicine)]

-G. Santulli* (* co-Corresponding Author), G. Pagano, C. Sardu, W. Xie, S. Reiken, S. L. D'Ascia, M. Cannone, N. Marziliano, B. Trimarco, T. A. Guise, A. Lacampagne and A. Marks. Calcium release channel RYR2 regulates insulin release and glucose homeostasis. J Clin Invest. 2015;125:1968-78. https://doi.org/10.1172/jci79273; PMID:25844899.

-I. Berindan-Neagoe, GA. Calin, C. Francastel, F. Hubé, G. Santulli. Micromanipulating the behavior via microRNA: New lessons from Drosophila. Non-Coding RNA. 2015;1:285-288. https://doi.org/10.3390/ncrna1030285; PMCID: PMC5932552

-G. Santulli and A. R. Marks. Essential roles of intracellular calcium release channels in muscle, brain, metabolism, and aging. Curr Mol Pharmacol. 2015;8:206-22. https://doi.org/10.2174/1874467208666150507105105; PMID:25966694.

-G. Santulli. MicroRNAs distinctively regulate vascular smooth muscle and endothelial cells: Functional implications in angiogenesis, atherosclerosis, and in-stent restenosis. Adv Exp Med Biol. 2015;887:53-77. https://doi.org/10.1007/978-3-319-22380-3_4; PMID:26662986.

-G. Santulli, C. Borras, J. Bousquet, L. Calzà, A. Cano, M. Illario, C. Franceschi, G. Liotta, M. Maggio, W. D. Molloy, N. Montuori, R. O'Caoimh, F. Orfila, A. P. Rauter, A. Santoro and G. Iaccarino. Models for preclinical studies in aging-related disorders: One is not for all. Transl Med UniSa. 2015;13:4-12. PMID:27042427.

- G. Santulli. An interview with Gaetano Santulli. European Medical Journal (EMJ). 2015;3.2:35-37. https://tinyurl.com/4fsu3h2u

-C. Francastel, F. Hubé, S. Mani, G. Santulli, JH. Taube, Z. Szweykowska-Kulinska. Mitochondrial calcium overload and oxidative stress in cardiomyocytes are linked by microRNA-25. Non-Coding RNA. 2015;1:167-169. https://doi.org/10.3390%2Fncrna1020167; PMCID: PMC5932546.

-G. Santulli. Effects of low-carbohydrate and low-fat diets. Ann Intern Med. 2015;162:392. https://doi.org/10.7326/l15-5057-3; PMID:25732288.

-G. Santulli. Β-blockers in diabetic patients with heart failure. JAMA Internal Medicine. 2015;175:657. https://doi.org/10.1001/jamainternmed.2014.8009; PMID:25844751.

-J. Novák, V. Olejníčková, N. Tkáčová and G. Santulli. Mechanistic role of microRNAs in coupling lipid metabolism and atherosclerosis. Adv Exp Med Biol. 2015;887:79-100. https://doi.org/10.1007/978-3-319-22380-3_5; PMID:26662987.

-E. Cipolletta, M. R. Rusciano, A. S. Maione, G. Santulli, D. Sorriento, C. Del Giudice, M. Ciccarelli, A. Franco, C. Crola, P. Campiglia, M. Sala, I. Gomez-Monterrey, N. De Luca, B. Trimarco, G. Iaccarino and M. Illario. Targeting the camkii/erk interaction in the heart prevents cardiac hypertrophy. PLoS One. 2015;10:e0130477. https://doi.org/10.1371/journal.pone.0130477; PMID:26110816.

-M. Ferracin, D. Gautheret, F. Hubé, SA. Mani, JS. Mattick, UA. Ørom, G. Santulli, RK. Slotkin, Z. Szweykowska-Kulinska, JH. Taube, F. Vazquez, JH. Yang Diabetes Ask1ng for trouble: Terminating microRNA biogenesis in ER stress and Myoregulin is a novel modulator of calcium handling and excitation–contraction coupling: Hunting for Easter eggs in the concealed microproteome. Non-Coding RNA. 2015;1:87-93. https://doi.org/10.3390/ncrna1010087.

-G. Santulli. Exploiting microRNA specificity and selectivity: Paving a sustainable path towards precision medicine. Adv Exp Med Biol. 2015;888:1-3. https://doi.org/10.1007/978-3-319-22671-2_1; PMID:26663175.

-FT. Nguyen, C. Patel, G. Santulli. An interview with Gaetano Santulli. JCI Impact 2014; September Issue:p10. Editor’s picks. https://www.jci.org/posts/200

-Q. Yuan, Z. Chen, G. Santulli* (*co-First Authorship), L. Gu, Z. G. Yang, Z. Q. Yuan, Y. T. Zhao, H. B. Xin, K. Y. Deng, S. Q. Wang and G. Ji. Functional role of Calstabin2 in age-related cardiac alterations. Sci Rep. 2014;4:7425. https://doi.org/10.1038/srep07425; PMID:25502776.

-A. Umanskaya, G. Santulli * (*co-First Authorship), W. Xie, D. Andersson, S. R. Reiken and A. Marks. Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging. Proc Natl Acad Sci U S A (PNAS). 2014;111:15250-5. https://doi.org/10.1073/pnas.1412754111; PMID:25288763.

-D. Sorriento, M. Ciccarelli, G. Santulli, M. Illario, B. Trimarco and G. Iaccarino. Trafficking GRK2: Cellular and metabolic consequences of GRK2 subcellular localization. Transl Med UniSa. 2014;10:3-7. PMID:25147759.

-G. L. Soares-Filho, S. Machado, O. Arias-Carrión, G. Santulli, C. T. Mesquita, F. Cosci, A. C. Silva and A. E. Nardi. Myocardial perfusion imaging study of CO₂-induced panic attack. Am J Cardiol. 2014;113:384-8. https://doi.org/10.1016/j.amjcard.2013.09.035; PMID:24188891.

-G. Santulli. MicroRNA-directed gene delivery selectively targets VSMCs to prevent restenosis. Journal of Clinical Investigation. 2014;online-only. https://www.jci.org/this-month/2014/9.

-G. L. Soares-Filho, O. Arias-Carrión, G. Santulli, A. C. Silva, S. Machado, A. M. Valenca and A. E. Nardi. Chest pain, panic disorder and coronary artery disease: A systematic review. CNS Neurol Disord Drug Targets. 2014;13:992-1001. https://doi.org/10.2174/1871527313666140612141500; PMID:24923348.

-C. Sardu, R. Marfella, G. Santulli and G. Paolisso. Functional role of miRNA in cardiac resynchronization therapy. Pharmacogenomics. 2014;15:1159-68. https://doi.org/10.2217/pgs.14.76; PMID:25084208.

-C. Sardu, R. Marfella and G. Santulli. Impact of diabetes mellitus on the clinical response to cardiac resynchronization therapy in elderly people. J Cardiovasc Transl Res. 2014;7:362-8. https://doi.org/10.1007/s12265-014-9545-9; PMID:24500410.

-C. Sardu, G. Carreras, S. Katsanos, V. Kamperidis, M. C. Pace, M. B. Passavanti, I. Fava, P. Paolisso, G. Pieretti, G. F. Nicoletti, G. Santulli, G. Paolisso and R. Marfella. Metabolic syndrome is associated with a poor outcome in patients affected by outflow tract premature ventricular contractions treated by catheter ablation. BMC Cardiovasc Disord. 2014;14:176. https://doi.org/10.1186/1471-2261-14-176; PMID:25480761.

-G. Santulli, A. Wronska, K. Uryu, T. G. Diacovo, M. Gao, S. O. Marx, J. Kitajewski, J. M. Chilton, K. M. Akat, T. Tuschl, A. Marks and H. Totary. A selective microRNA-based strategy inhibits restenosis while preserving endothelial function. J Clin Invest. 2014;124:4102-14. https://doi.org/10.1172/jci76069; PMID:25133430.

-G. Santulli, G. Iaccarino, N. De Luca, B. Trimarco and G. Condorelli. Atrial fibrillation and micrornas. Front Physiol. 2014;5:15. https://doi.org/10.3389/fphys.2014.00015; PMID:24478726.

-G. Santulli. Adrenal signaling in heart failure: Something more than a distant ship's smoke on the horizon. Hypertension. 2014;63:215-6. https://doi.org/10.1161/hypertensionaha.113.02382; PMID:24218430.

-G. Santulli. Angiopoietin-like proteins: A comprehensive look. Front Endocrinol. 2014;5:4. https://doi.org/10.3389/fendo.2014.00004; PMID:24478758.

-M. Ciccarelli, M. R. Rusciano, D. Sorriento, M. F. Basilicata, G. Santulli, P. Campiglia, A. Bertamino, N. De Luca, B. Trimarco, G. Iaccarino and M. Illario. CaMKII protects MKP-1 from proteasome degradation in endothelial cells. Cell Signal. 2014;26:2167-74. https://doi.org/10.1016/j.cellsig.2014.06.009; PMID:25007998.

-W. Xie, G. Santulli, X. Guo, M. Gao, B. X. Chen and A. R. Marks. Imaging atrial arrhythmic intracellular calcium in intact heart. J Mol Cell Cardiol. 2013;64:120-3. https://doi.org/10.1016/j.yjmcc.2013.09.003; PMID:24041536.

-G. Santulli, B. Trimarco and G. Iaccarino. G-protein-coupled receptor kinase 2 and hypertension: Molecular insights and pathophysiological mechanisms. High Blood Press Cardiovasc Prev. 2013;20:5-12. https://doi.org/10.1007/s40292-013-0001-8; PMID:23532739.

-G. Santulli and H. Totary-Jain. Tailoring mtor-based therapy: Molecular evidence and clinical challenges. Pharmacogenomics. 2013;14:1517-26. https://doi.org/10.2217/pgs.13.143; PMID:24024901.

-G. Santulli and G. Iaccarino. Pinpointing beta adrenergic receptor in ageing pathophysiology: Victim or executioner? Evidence from crime scenes. Immun Ageing. 2013;10:10. https://doi.org/10.1186/1742-4933-10-10; PMID:23497413.

-G. Santulli, M. Ciccarelli, B. Trimarco and G. Iaccarino. Physical activity ameliorates cardiovascular health in elderly subjects: The functional role of the β adrenergic system. Front Physiol. 2013;4:209. https://doi.org/10.3389/fphys.2013.00209; PMID:23964243.

-M. Ciccarelli, G. Santulli, V. Pascale, B. Trimarco and G. Iaccarino. Adrenergic receptors and metabolism: Role in development of cardiovascular disease. Front Physiol. 2013;4:265. https://doi.org/10.3389/fphys.2013.00265; PMID:24106479.

-G. Santulli, Iaccarino G. The essential role of β2-adrenergic receptor in glucose homeostasis. PLoS One. 2013;e-pages. https://tinyurl.com/a64k72wa

-Matarese A, G. Santulli. Angiogenesis in chronic obstructive pulmonary disease: A translational appraisal. Nature Prec. 2012; https://doi.org/:10.1038/npre.2012.7112.1.

-D. Sorriento, G. Santulli, C. Del Giudice, A. Anastasio, B. Trimarco and G. Iaccarino. Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo. Hypertension. 2012;60:129-36. https://doi.org/10.1161/hypertensionaha.111.189605; PMID:22665130.

-G. Santulli, A. Lombardi, D. Sorriento, A. Anastasio, C. Del Giudice, P. Formisano, F. Béguinot, B. Trimarco, C. Miele and G. Iaccarino. Age-related impairment in insulin release: The essential role of β(2)-adrenergic receptor. Diabetes. 2012;61:692-701. https://doi.org/10.2337/db11-1027; PMID:22315324.

-G. Santulli, L. D'Ascia S and C. D'Ascia. Development of atrial fibrillation in recipients of cardiac resynchronization therapy: The role of atrial reverse remodelling. Can J Cardiol. 2012;28:245.e17; https://doi.org/10.1016/j.cjca.2011.11.001; PMID:22244772.

-G. Santulli, S. D'Ascia, V. Marino and C. D'Ascia. Atrial function in patients undergoing CRT. JACC Cardiovasc Imaging. 2012;5:124-5. https://doi.org/10.1016/j.jcmg.2011.11.002; PMID:22239903.

-G. Santulli, S. D'Ascia and C. D'Ascia. Regarding the impact of left ventricular size on response to cardiac resynchronization therapy. Am Heart J. 2012;163:e11. https://doi.org/10.1016/j.ahj.2012.01.001; PMID:22520543.

-G. Santulli and C. D'Ascia. Atrial remodelling in echocardiographic super-responders to cardiac resynchronization therapy. Heart. 2012;98:517; https://doi.org/10.1136/heartjnl-2012-301731; PMID:22350031.

-G. Santulli, E. Cipolletta, D. Sorriento, C. Del Giudice, A. Anastasio, S. Monaco, A. S. Maione, G. Condorelli, A. Puca, B. Trimarco, M. Illario and G. Iaccarino. Camk4 gene deletion induces hypertension. J Am Heart Assoc. 2012;1:e001081. https://doi.org/10.1161/jaha.112.001081; PMID:23130158.

-G. Santulli. Thrombolysis outcomes in acute ischemic stroke patients with prior stroke and diabetes mellitus. Neurology. 2012;78:840. https://doi.org/10.1212/WNL.0b013e31824de51b; PMID:22411960.

-G. Santulli. Coronary heart disease risk factors and mortality. JAMA. 2012;307:1137; https://doi.org/10.1001/jama.2012.323; PMID:22436947.

-A. Matarese and G. Santulli. Angiogenesis in chronic obstructive pulmonary disease: A translational appraisal. Transl Med UniSa. 2012;3:49-56. PMID:23905052.

-A. Fusco, G. Santulli, D. Sorriento, E. Cipolletta, C. Garbi, G. W. Dorn, 2nd, B. Trimarco, A. Feliciello and G. Iaccarino. Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis. Cell Signal. 2012;24:468-475. https://doi.org/10.1016/j.cellsig.2011.09.026; PMID:21983013.

-G. Santulli, M Chiariello, C D’Ascia, S. D’Ascia. Role of cardiac resynchronization therapy in the development of new-onset atrial fibrillation: A single-center prospective study. Nature Prec. 2012; https://www.nature.com/articles/npre.2012.7137.1.

-G. Santulli, A. Campanile, L. Spinelli, E. Assante di Panzillo, M. Ciccarelli, B. Trimarco and G. Iaccarino. G protein-coupled receptor kinase 2 in patients with acute myocardial infarction. Am J Cardiol. 2011;107:1125-30. https://doi.org/10.1016/j.amjcard.2010.12.006; PMID:21296320.

-G. Santulli, M. F. Basilicata, M. De Simone, C. Del Giudice, A. Anastasio, D. Sorriento, M. Saviano, A. Del Gatto, B. Trimarco, C. Pedone, L. Zaccaro and G. Iaccarino. Evaluation of the anti-angiogenic properties of the new selective αvβ3 integrin antagonist RGDECHIhcit. J Transl Med. 2011;9:7. https://doi.org/10.1186/1479-5876-9-7; PMID:21232121.

-A. Perino, A. Ghigo, E. Ferrero, F. Morello, G. Santulli, G. S. Baillie, F. Damilano, A. J. Dunlop, C. Pawson, R. Walser, R. Levi, F. Altruda, L. Silengo, L. K. Langeberg, G. Neubauer, S. Heymans, G. Lembo, M. P. Wymann, R. Wetzker, M. D. Houslay, G. Iaccarino, J. D. Scott and E. Hirsch. Integrating cardiac PIP3 and camp signaling through a pka anchoring function of p110γ. Mol Cell. 2011;42:84-95. https://doi.org/10.1016/j.molcel.2011.01.030; PMID:21474070. [Journal Cover]

-S. L. D'Ascia, C. D'Ascia, V. Marino, A. Lombardi, R. Santulli, M. Chiariello and G. Santulli. Cardiac resynchronisation therapy response predicts occurrence of atrial fibrillation in non-ischaemic dilated cardiomyopathy. Int J Clin Pract. 2011;65:1149-55. https://doi.org/10.1111/j.1742-1241.2011.02732.x; PMID:21995693.

-M. Ciccarelli, D. Sorriento, E. Cipolletta, G. Santulli, A. Fusco, R. H. Zhou, A. D. Eckhart, K. Peppel, W. J. Koch, B. Trimarco and G. Iaccarino. Impaired neoangiogenesis in β₂-adrenoceptor gene-deficient mice: Restoration by intravascular human β₂-adrenoceptor gene transfer and role of nfκb and creb transcription factors. British Journal of Pharmacology. 2011;162:712-21. https://doi.org/10.1111/j.1476-5381.2010.01078.x; PMID:20958287.

-D. Sorriento, G. Santulli, A. Fusco, A. Anastasio, B. Trimarco and G. Iaccarino. Intracardiac injection of Ad-GRK5-NT reduces left ventricular hypertrophy by inhibiting NF-kappaB-dependent hypertrophic gene expression. Hypertension. 2010;56:696-704. https://doi.org/10.1161/hypertensionaha.110.155960; PMID:20660817.

-G. Galasso, G. Santulli, F. Piscione, R. De Rosa, V. Trimarco, R. Piccolo, S. Cassese, G. Iaccarino, B. Trimarco and M. Chiariello. The GPIIIA PlA2 polymorphism is associated with an increased risk of cardiovascular adverse events. BMC Cardiovasc Disord. 2010;10:41. https://doi.org/10.1186/1471-2261-10-41; PMID:20846430.

-S. L. D'Ascia, G. Santulli, V. Liguori, V. Marino, C. Arturo, M. Chiariello and C. D'Ascia. Advanced algorithms can lead to electrocardiographic misinterpretations. Int J Cardiol. 2010;141:e34-6. https://doi.org/10.1016/j.ijcard.2008.11.144; PMID:19136171.

-D. Sorriento, A. Campanile, G. Santulli, E. Leggiero, L. Pastore, B. Trimarco and G. Iaccarino. A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of nfkappab activity. Mol Cancer. 2009;8:97. https://doi.org/10.1186/1476-4598-8-97; PMID:19900276.

-G. Santulli, M. Ciccarelli, G. Palumbo, A. Campanile, G. Galasso, B. Ziaco, G. G. Altobelli, V. Cimini, F. Piscione, L. D. D'Andrea, C. Pedone, B. Trimarco and G. Iaccarino. In vivo properties of the proangiogenic peptide QK. J Transl Med. 2009;7:41. https://doi.org/10.1186/1479-5876-7-41; PMID:19505323.

-F. Oriente, S. Iovino, A. Cassese, C. Romano, C. Miele, G. Troncone, M. Balletta, A. Perfetti, G. Santulli, G. Iaccarino, R. Valentino, F. Beguinot and P. Formisano. Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase c-beta activity and tgf-beta1 expression. Diabetologia. 2009;52:2642-52. https://doi.org/10.1007/s00125-009-1528-z; PMID:19789852.

-E. Cipolletta, A. Campanile, G. Santulli, E. Sanzari, D. Leosco, P. Campiglia, B. Trimarco and G. Iaccarino. The G protein coupled receptor kinase 2 plays an essential role in beta-adrenergic receptor-induced insulin resistance. Cardiovasc Res. 2009;84:407-15. https://doi.org/10.1093/cvr/cvp252; PMID:19620130.

-D. Sorriento, M. Ciccarelli, G. Santulli, A. Campanile, G. G. Altobelli, V. Cimini, G. Galasso, D. Astone, F. Piscione, L. Pastore, B. Trimarco and G. Iaccarino. The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of ikappab alpha. Proc Natl Acad Sci U S A (PNAS). 2008;105:17818-23. https://doi.org/10.1073/pnas.0804446105; PMID:19008357.

-R. Izzo, E. Cipolletta, M. Ciccarelli, A. Campanile, G. Santulli, G. Palumbo, A. Vasta, S. Formisano, B. Trimarco and G. Iaccarino. Enhanced GRK2 expression and desensitization of betaAR vasodilatation in hypertensive patients. Clin Transl Sci. 2008;1:215-20. https://doi.org/10.1111/j.1752-8062.2008.00050.x; PMID:20443852.

-M. Ciccarelli, G. Santulli, A. Campanile, G. Galasso, P. Cervèro, G. G. Altobelli, V. Cimini, L. Pastore, F. Piscione, B. Trimarco and G. Iaccarino. Endothelial Alpha1-adrenoceptors regulate neo-angiogenesis. British Journal of Pharmacology. 2008;153:936-46. https://doi.org/10.1038/sj.bjp.0707637; PMID:18084315.

-F. Lanni, G. Santulli, R. Izzo, S. Rubattu, B. Zanda, M. Volpe, G. Iaccarino and B. Trimarco. The Pl(A1/A2) polymorphism of glycoprotein IIIa and cerebrovascular events in hypertension: Increased risk of ischemic stroke in high-risk patients. J Hypertens. 2007;25:551-6. https://doi.org/10.1097/HJH.0b013e328013cd67; PMID:17278970.

-M. Ciccarelli, E. Cipolletta, G. Santulli, A. Campanile, K. Pumiglia, P. Cervero, L. Pastore, D. Astone, B. Trimarco and G. Iaccarino. Endothelial Beta₂ adrenergic signaling to AKT: Role of G_i and SRC. Cell Signal. 2007;19:1949-55. https://doi.org/10.1016/j.cellsig.2007.05.007; PMID:17629454.

-G. Iaccarino, M. Ciccarelli, D. Sorriento, G. Galasso, A. Campanile, G. Santulli, E. Cipolletta, V. Cerullo, V. Cimini, GG. Altobelli, F. Piscione, O. Priante, L. Pastore, M. Chiariello, F. Salvatore, WJ. Koch and B. Trimarco. Ischemic neoangiogenesis enhanced by Beta₂-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system. Circulation Research. 2005;97:1182-9. https://doi.org/10.1161/01.RES.0000191541.06788.bb; PMID:16239589.

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