Varzideh, Fahimeh, Imma Forzano, Emanuele Farroni, Pasquale Mone, Urna Kansakar, and Gaetano Santulli. “Macrophages Regulate Inflammatory Vascular Remodeling in Pulmonary Hypertension.”. Hypertension (Dallas, Tex. : 1979) 82, no. 3 (2025): 460-62. https://doi.org/10.1161/HYPERTENSIONAHA.124.24309.
Publications by Year: 2025
2025
Tobias, Jane, Stephen DiDonato, Lisa Whitfield-Harris, Carol Okupniak, Gabrielle Santulli, Nimmy Das, and Marie Marino. “Creation of a Novel Virtual Reality Simulation to Increase Nursing Skills in Management of Workplace Violence.”. The Journal of Nursing Administration, 2025. https://doi.org/10.1097/NNA.0000000000001548.
OBJECTIVE: This article presents the design, development, and implementation of a novel and innovative virtual reality (VR) simulation aimed at increasing nursing skills in identifying, managing, and deescalating workplace violence (WPV) incidents and mitigating the effects after critical incidents.
BACKGROUND: The ANA reports that 1 in 4 nurses in the United States experience workplace assault annually, highlighting the novel role of VR simulations in educating and preparing nurses to recognize, address, and minimize the impact of WPV.
METHODS: A multidisciplinary team designed and implemented a VR simulation based on real WPV incidents reported by nurses in an urban health system, enlisting a film and video company's expertise to bring scenarios to life, addressing a critical gap.
CONCLUSIONS: This article discusses the collaborative creation of simulations using VR as a novel strategy for educating nurses on identification, management, and deescalation of incidents of WPV and mitigating the effects of WPV after critical incidents.
Tung, Cheryl, Fahimeh Varzideh, Emanuele Farroni, Pasquale Mone, Urna Kansakar, Stanislovas S Jankauskas, and Gaetano Santulli. “Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential.”. International Journal of Molecular Sciences 26, no. 3 (2025). https://doi.org/10.3390/ijms26030944.
Mitochondria serve an essential metabolic and energetic role in cellular activity, and their dysfunction has been implicated in a wide range of disorders, including cardiovascular conditions, neurodegenerative disorders, and metabolic syndromes. Mitochondria-targeted therapies, such as Elamipretide (SS-31, MTP-131, Bendavia), have consequently emerged as a topic of scientific and clinical interest. Elamipretide has a unique structure allowing for uptake in a variety of cell types and highly selective mitochondrial targeting. This mitochondria-targeting tetrapeptide selectively binds cardiolipin (CL), a lipid found in the inner mitochondrial membrane, thus stabilizing mitochondrial cristae structure, reducing oxidative stress, and enhancing adenosine triphosphate (ATP) production. Preclinical studies have demonstrated the protective and restorative efficacy of Elamipretide in models of heart failure, neurodegeneration, ischemia-reperfusion injury, metabolic syndromes, and muscle atrophy and weakness. Clinical trials such as PROGRESS-HF, TAZPOWER, MMPOWER-3, and ReCLAIM elaborate on preclinical findings and highlight the significant therapeutic potential of Elamipretide. Further research may expand its application to other diseases involving mitochondrial dysfunction as well as investigate long-term efficacy and safety of the drug. The following review synthesizes current knowledge of the structure, mechanisms of action, and the promising therapeutic role of Elamipretide in stabilizing mitochondrial fitness, improving mitochondrial bioenergetics, and minimizing oxidative stress.
Santulli, Gaetano, Markus W Hollmann, Christina M Pabelick, and Johannes J Van Lieshout. “Editorial: Insights in Clinical and Translational Physiology: 2023.”. Frontiers in Physiology 16 (2025): 1508102. https://doi.org/10.3389/fphys.2025.1508102.
Jankauskas, Stanislovas S, Fahimeh Varzideh, Emanuele Farroni, Pasquale Mone, Urna Kansakar, and Gaetano Santulli. “The Selective Sorting of MiR-4432 into Endothelial Extracellular Vesicles Is Controlled by a Specific RNA Binding Protein: New Insights in the Pathophysiology of Venous Malformations.”. The British Journal of Dermatology, 2025. https://doi.org/10.1093/bjd/ljaf033.
Qin, Yifei, and Gaetano Santulli. “Invited Perspective: Incense Burning and Cardiovascular Risk-A Rising Concern.”. Environmental Health Perspectives 133, no. 1 (2025): 11304. https://doi.org/10.1289/EHP16598.
Fisman, Enrique Z, Francisco Westermeier, and Gaetano Santulli. “A New Kid in Town: Cardiovascular Diabetology-Endocrinology Reports.”. Cardiovascular Diabetology 24, no. 1 (2025): 30. https://doi.org/10.1186/s12933-025-02602-1.
Varzideh, Fahimeh, Emanuele Farroni, Urna Kaunsakar, Mahaba Eiwaz, Stanislovas S Jankauskas, and Gaetano Santulli. “TMAO Accelerates Cellular Aging by Disrupting Endoplasmic Reticulum Integrity and Mitochondrial Unfolded Protein Response.”. Cellular and Molecular Life Sciences : CMLS 82, no. 1 (2025): 53. https://doi.org/10.1007/s00018-024-05546-z.
Forzano, Imma, Scott Wilson, Emanuele Farroni, Brandon Wang, and Gaetano Santulli. “Beneficial Effects of Early Rehabilitation in Patients With Acute Heart Failure.”. Critical Care Medicine 53, no. 1 (2025): e198-e200. https://doi.org/10.1097/CCM.0000000000006491.